COMPARISON OF THERAPEUTIC EFFECTS OF VVITAMIN C AND COQ10 IN REDUCING OF DAMAGED CELLS IN MICE HIPPOCAMPUS FOLLOWING ISCHEMIA-REPERFUSION

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HASSANSHAHI JALAL; HASSANSHAHI GHOLAMHOSSEIN; ZAMANI MOHAMMAD; HAKIMIZADEH ELHAM; SOLEYMANI MANSOUREH

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Journal: Journal of Mazandaran University of Medical Sciences Year:2012 | Volume:22 | Issue:94 Page(s): 1-13

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Title

COMPARISON OF THERAPEUTIC EFFECTS OF VVITAMIN C AND COQ10 IN REDUCING OF DAMAGED CELLS IN MICE HIPPOCAMPUS FOLLOWING ISCHEMIA-REPERFUSION

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Keywords

HIPPOCAMPUSQ2

ISCHEMIA-REPERFUSIONQ2

NEUROPROTECTIVE EFFECTQ2

COQ10Q2

ASCORBIC ACID J MAZANDQ3

Abstract

Background and purpose: Vitamin C and COQ10 are known as two potentantioxidants. We studied the protective Role of COQ10 and ascorbic acid against ISCHEMIA-REPERFUSION. Finally, we have compared the therapeutic effect of these two together.Materials and methods: 35 male balb-Cwere divided into seven subgroups. Includes five groups: intact, ischemic Control, sham Control and treatment groups with COQ10 and treatment groups with ascorbic acid. In treatment groups, the mice treated with COQ10 and vit C as Pre-Treatment for a week. Then, ischemia induced by Common Carotid artery ligation. The mice post-treated with COQ10and ascorbic acid for a week. Nissl staining applied to counting necrotic Cells of HIPPOCAMPUS. TUNNEL kit was used to quantify apoptotic Cell death while to short term memory scale, we apply y-maze and shuttle box tests.Results: High rate of apoptosis was seen in ischemic group associated with significantly short term memory loss. In the treatment groups with these antioxidants, Cell death was significantly lower than the ischemic Control group. Between treatment groups, group treated with COQ10 was less neuronal death than the group treated with ascorbic acid.Conclusion: According to the results of this study, ascorbic acid and COQ10 intake significantly reduced Cell death and decreased memory loss. But the antioxidant effect of COQ10 is stronger than vitamin C in this zone of brain.

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APA: Copy

HASSANSHAHI, JALAL, HASSANSHAHI, GHOLAMHOSSEIN, ZAMANI, MOHAMMAD, HAKIMIZADEH, ELHAM, & SOLEYMANI, MANSOUREH. (2012). COMPARISON OF THERAPEUTIC EFFECTS OF VVITAMIN C AND COQ10 IN REDUCING OF DAMAGED CELLS IN MICE HIPPOCAMPUS FOLLOWING ISCHEMIA-REPERFUSION. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(94), 1-13. SID. https://sid.ir/paper/44204/en

Vancouver: Copy

HASSANSHAHI JALAL, HASSANSHAHI GHOLAMHOSSEIN, ZAMANI MOHAMMAD, HAKIMIZADEH ELHAM, SOLEYMANI MANSOUREH. COMPARISON OF THERAPEUTIC EFFECTS OF VVITAMIN C AND COQ10 IN REDUCING OF DAMAGED CELLS IN MICE HIPPOCAMPUS FOLLOWING ISCHEMIA-REPERFUSION. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(94):1-13. Available from: https://sid.ir/paper/44204/en

IEEE: Copy

JALAL HASSANSHAHI, GHOLAMHOSSEIN HASSANSHAHI, MOHAMMAD ZAMANI, ELHAM HAKIMIZADEH, and MANSOUREH SOLEYMANI, “COMPARISON OF THERAPEUTIC EFFECTS OF VVITAMIN C AND COQ10 IN REDUCING OF DAMAGED CELLS IN MICE HIPPOCAMPUS FOLLOWING ISCHEMIA-REPERFUSION,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 94, pp. 1–13, 2012, [Online]. Available: https://sid.ir/paper/44204/en

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