EFFECT OF HUMAN CHORIONIC GONADOTROPIN AND VITAMINE E ON CELLULAR DENSITY OF CA1 HIPPOCAMPAL AREA, LEARNING ABILITY AND MEMORY, FOLLOWING ISCHEMIA - REPERFUSION INJURY IN MICE

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BABAHAJIAN A.; RASOULI H.; KATEBI M.; SARVEAZAD A.; SOLEIMANI M.; NOBAKHT M.

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Journal: Journal of Gorgan University of Medical Sciences Year:2014 | Volume:15 | Issue:4 (48) Page(s): 23-28

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Title

EFFECT OF HUMAN CHORIONIC GONADOTROPIN AND VITAMINE E ON CELLULAR DENSITY OF CA1 HIPPOCAMPAL AREA, LEARNING ABILITY AND MEMORY, FOLLOWING ISCHEMIA - REPERFUSION INJURY IN MICE

Author(s)

Keywords

ISCHEMIAQ2

REPERFUSIONQ2

HIPPOCAMPUSQ2

CA1 AREAQ2

HUMAN CHORIONIC GONADOTROPINQ2

VITAMINE EQ2

Abstract

Background and Objective: Reduction in cerebral blood flow following cereblal ISCHEMIA cause the production of oxygen free radicals and finally leads to brain tissue destruction. Pyramidal cells of the CA1 region of HIPPOCAMPUS are highly sensitive to hypoxic condition. This study was done to determine the effect of HUMAN CHORIONIC GONADOTROPIN (hCG) and VITAMINE E on cellular density of CA1 hippocampal area, learning ability and memory, following ISCHEMIA - REPERFUSION injury in mice.Materials and Methods: This experimental study was done on 40 male mice in 5 groups as follow: sham control, ISCHEMIA, hCG treated, VITAMINE E treated and hCG+vitamine E treated groups. Single dose of vitamin E was injected intraperitonaly during the establishment of REPERFUSION and hCG was injected from 48h after ISCHEMIA for 5 days. Folowing the treatment period, mice brains were fixated by transcardial perfusion and stained by nissle method. The shuttle box was used to evaluate the learning memory.Results: Co-administartion of VITAMINE E and hCG, significantly increased the cell numbers in HIPPOCAMPUS compared to the ischemic group (P<0.001). Also learning and memory improved in treatment group in comparison with ISCHEMIA group (P<0.05).Conclusion: Co-administration of vitamin E and hCG improved ISCHEMIA-induced neurodegenration and memory impairment.

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APA: Copy

BABAHAJIAN, A., RASOULI, H., KATEBI, M., SARVEAZAD, A., SOLEIMANI, M., & NOBAKHT, M.. (2014). EFFECT OF HUMAN CHORIONIC GONADOTROPIN AND VITAMINE E ON CELLULAR DENSITY OF CA1 HIPPOCAMPAL AREA, LEARNING ABILITY AND MEMORY, FOLLOWING ISCHEMIA - REPERFUSION INJURY IN MICE . JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 15(4 (48)), 23-28. SID. https://sid.ir/paper/78873/en

Vancouver: Copy

BABAHAJIAN A., RASOULI H., KATEBI M., SARVEAZAD A., SOLEIMANI M., NOBAKHT M.. EFFECT OF HUMAN CHORIONIC GONADOTROPIN AND VITAMINE E ON CELLULAR DENSITY OF CA1 HIPPOCAMPAL AREA, LEARNING ABILITY AND MEMORY, FOLLOWING ISCHEMIA - REPERFUSION INJURY IN MICE . JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;15(4 (48)):23-28. Available from: https://sid.ir/paper/78873/en

IEEE: Copy

A. BABAHAJIAN, H. RASOULI, M. KATEBI, A. SARVEAZAD, M. SOLEIMANI, and M. NOBAKHT, “EFFECT OF HUMAN CHORIONIC GONADOTROPIN AND VITAMINE E ON CELLULAR DENSITY OF CA1 HIPPOCAMPAL AREA, LEARNING ABILITY AND MEMORY, FOLLOWING ISCHEMIA - REPERFUSION INJURY IN MICE ,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 4 (48), pp. 23–28, 2014, [Online]. Available: https://sid.ir/paper/78873/en

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