PREVALENCE OF HELICOBACTERPYLORI CAGE GENOTYPES, IN PATIENTS WITH NON-ULCER DYSPEPSIA, PEPTIC ULCER AND GASTRIC CARCINOMA

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SHIRAZI M.H.; BAGHERIFAM S.; POURMAND MOHAMMAD REZA; HAGHSHENAS M.R.; AGHA REZAEI MOHAGHEGH VAHIDEH

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:18 | Issue:64 Page(s): 37-43

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Title

PREVALENCE OF HELICOBACTERPYLORI CAGE GENOTYPES, IN PATIENTS WITH NON-ULCER DYSPEPSIA, PEPTIC ULCER AND GASTRIC CARCINOMA

Author(s)

Keywords

HELICOBACTER PYLORIQ3

CAGEQ3

NUDQ3

CANCERQ2

Abstract

Background and Purpose: HELICOBACTER PYLORI are a bacterial pathogen evolved to chronically colonize the gastric epithelium and causes gastritis, peptic ulcers, and even gastric malignancies in few infected humans. More recently, a pathogenicity island has been identified within the H pylori genome that contains a cluster of genes, including CAGE. The aim of the current study was to investigate the prevalence of CAGE genotypes of H pylori isolates from patients with NUD (Non Ulcer Dyspepsia), peptic ulcer and CANCER.Materials and Methods: 150 Gastric biopsy specimens obtained from patients were inoculated onto a Brucella Columbia Agar containing 5% sheep for 3 to 5 days at 37°C under micro aerobic conditions (5% O2, 5% CO2, and 90% N2). After DNA extraction, genotyping of the CAGE gene was performed by PCR amplification using the primers. PCR products were separated by 1% agarose gel electrophoresis and examined under UV illumination.Results: Of 92 positive cultures, 34, 28, 20, and 10 isolations were obtained from patients with NUD, duodenal ulcers (DU), gastric ulcers (GU) and gastric CANCER (GC), respectively. The frequency of CAGE gene was 88/24%, 100%, 85%, 100%and within isolates of patients with NUD, DU, GU and GC, respectively.Conclusion: The presence of CAGE in patients with HELICOBACTER PYLORI infection is not a marker for predicting or diagnosing the resultant diseases.

Cites

ASSOCIATION BETWEEN GASTRIC DISORDERS AND CAGA OR CAGE IN IRANIAN PATIENTS

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APA: Copy

SHIRAZI, M.H., POURMAND, MOHAMMAD REZA, HAGHSHENAS, M.R., AGHA REZAEI MOHAGHEGH, VAHIDEH, & BAGHERIFAM, S.. (2008). PREVALENCE OF HELICOBACTERPYLORI CAGE GENOTYPES, IN PATIENTS WITH NON-ULCER DYSPEPSIA, PEPTIC ULCER AND GASTRIC CARCINOMA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 18(64), 37-43. SID. https://sid.ir/paper/44448/en

Vancouver: Copy

SHIRAZI M.H., POURMAND MOHAMMAD REZA, HAGHSHENAS M.R., AGHA REZAEI MOHAGHEGH VAHIDEH, BAGHERIFAM S.. PREVALENCE OF HELICOBACTERPYLORI CAGE GENOTYPES, IN PATIENTS WITH NON-ULCER DYSPEPSIA, PEPTIC ULCER AND GASTRIC CARCINOMA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;18(64):37-43. Available from: https://sid.ir/paper/44448/en

IEEE: Copy

M.H. SHIRAZI, MOHAMMAD REZA POURMAND, M.R. HAGHSHENAS, VAHIDEH AGHA REZAEI MOHAGHEGH, and S. BAGHERIFAM, “PREVALENCE OF HELICOBACTERPYLORI CAGE GENOTYPES, IN PATIENTS WITH NON-ULCER DYSPEPSIA, PEPTIC ULCER AND GASTRIC CARCINOMA,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 64, pp. 37–43, 2008, [Online]. Available: https://sid.ir/paper/44448/en

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