SUBACUTE EXPOSURE TO GASEOUS FORMALDEHYDE AND ITS EFFECT ON GSH AND MDA LEVELS IN LIVER TISSUE OF MALE ALBINO WISTAR RAT

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KHAVANIN ALI; DEHGHANI ASGHAR; RANJBARIAN MOHAMMAD; REZAZADEH AZARI MANSOUR; EMAMI AL AGHA MOHAMMAD SAJAD; AZIZIAN SARA

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Journal: Journal of Mazandaran University of Medical Sciences Year:2012 | Volume:22 | Issue:90 Page(s): 114-122

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Title

SUBACUTE EXPOSURE TO GASEOUS FORMALDEHYDE AND ITS EFFECT ON GSH AND MDA LEVELS IN LIVER TISSUE OF MALE ALBINO WISTAR RAT

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Keywords

FORMALDEHYDEQ2

OXIDATIVE STRESSQ2

REDUCED GLUTATHIONEQ2

LIPID PEROXIDATION AND MALONDIALDEHYDEQ3

Abstract

Background and purpose: Exposure to FORMALDEHYDE (FA), a highly-used chemical in industries, can induce serious health problems. Aim of this study was to explore the status of oxidant and antioxidant parameters in liver tissue of rats exposed to FA inhalation Materials and methods: Twenty-one male albino Wistar rats divided into 3 separate groups randomly (n=7). Rats in groups 1 and 2 were respectively exposed to atmospheres containing6 and 12 PPM FA continuously (8 hours/day, 14 days), while animals in group 3 which served as control group were not exposed to any stress source. The animals were anesthetized by CO2 and after decapitation, liver samples were collected and processed for estimation of MDA and GSH levels in the supernatant by spectrophotometric method in control and exposed groups. Data were analyzed bynonparametric tests and significance was expressed as P<0.05.Results: The present research findings showed statistically significant body weight loss in FA (12ppm) exposed group compared to the control and also FA (6ppm) exposed groups. However, a statistically significant decrease in liver weight and liver/body weight ratio was observed in the exposed groups compared to the control group (P<0.05). FA exposed groups showed a statistically significant decrease in GSH levelin liver tissue and statistically significant increase in MDA level in liver tissue (P<0.05). However, the levels of changes inbiochemical parametersin FA exposed groups were not dosedependent.Conclusion: The results of present study show that exposure to FORMALDEHYDE is toxic to liver tissue. Further research for exploring the toxicity of FA in occupationally exposed groups is recommended.

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APA: Copy

KHAVANIN, ALI, DEHGHANI, ASGHAR, RANJBARIAN, MOHAMMAD, REZAZADEH AZARI, MANSOUR, EMAMI AL AGHA, MOHAMMAD SAJAD, & AZIZIAN, SARA. (2012). SUBACUTE EXPOSURE TO GASEOUS FORMALDEHYDE AND ITS EFFECT ON GSH AND MDA LEVELS IN LIVER TISSUE OF MALE ALBINO WISTAR RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(90), 114-122. SID. https://sid.ir/paper/44476/en

Vancouver: Copy

KHAVANIN ALI, DEHGHANI ASGHAR, RANJBARIAN MOHAMMAD, REZAZADEH AZARI MANSOUR, EMAMI AL AGHA MOHAMMAD SAJAD, AZIZIAN SARA. SUBACUTE EXPOSURE TO GASEOUS FORMALDEHYDE AND ITS EFFECT ON GSH AND MDA LEVELS IN LIVER TISSUE OF MALE ALBINO WISTAR RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(90):114-122. Available from: https://sid.ir/paper/44476/en

IEEE: Copy

ALI KHAVANIN, ASGHAR DEHGHANI, MOHAMMAD RANJBARIAN, MANSOUR REZAZADEH AZARI, MOHAMMAD SAJAD EMAMI AL AGHA, and SARA AZIZIAN, “SUBACUTE EXPOSURE TO GASEOUS FORMALDEHYDE AND ITS EFFECT ON GSH AND MDA LEVELS IN LIVER TISSUE OF MALE ALBINO WISTAR RAT,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 90, pp. 114–122, 2012, [Online]. Available: https://sid.ir/paper/44476/en

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