CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF FERMENTED AND NON-FERMENTED EXTRACTS OF GARLIC

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RAVANBAKHSHIAN REYHANEH; BEHBAHANI MANDANA

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Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:27 | Issue:156 Page(s): 38-49

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Information Journal Paper

Title

CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF FERMENTED AND NON-FERMENTED EXTRACTS OF GARLIC

Author(s)

RAVANBAKHSHIAN REYHANEH | BEHBAHANI MANDANA | Issue Writer Certificate

Keywords

GARLICQ3

CYTOTOXICQ1

ANTIBACTERIALQ2

FERMENTATIONQ2

Abstract

Background and purpose: Allium sativum belongs to the Liliaceae family and is widely used infolk medicine. ANTIBACTERIAL, anticancer and antioxidant activity of this genus have been previouslyreported. Current study, aimed at investigating the CYTOTOXIC and ANTIBACTERIAL activity of fermented andnon-fermented extracts of A. sativum on breath cancer cells (MCF7), lymphocyte cells, and somepathogenic bacteria. Materials and methods: MCF-7 and lymphocyte cells were maintained in DMEM and RPMImedium supplemented with 10% Fetal Bovine Serum (FBS), respectively. CYTOTOXIC effect of themethanol extracts of fermented and non-fermented GARLICs was measured on MCF7 at differentconcentrations (6. 25, 12. 5, 25, 50, 75, 100, 150, 200, 300, 350, 400, 450, 500 μ g/ml) using MTT assay. The ANTIBACTERIAL properties of these extracts were also investigated against Staphylococcussaprophyticus, Proteus mirabilis, and Escherichia coli by disk diffusion. Results: The GARLIC fermented by Lactobacillus plantarum, strain1745, showed the highestcytotoxic activity (CC50 400μ g/ml) compared to strain 1058 (CC50 450μ g/ml) and natural flora (CC50>500μ g/ml). We observed a significant relationship between the flavonoid contents of GARLIC andcytotoxic activity (P value < 0. 05). Among these extracts, fermented GARLIC had the highest levels offlavonoid, CYTOTOXIC, and ANTIBACTERIAL activity. Conclusion: This study showed that lacto fermented GARLIC extract might be a good candidateagainst breast cancer cells and pathogenic bacteria.

Cites

The in vitro survey of cytotoxic activities extracts of garlic and green tea

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APA: Copy

RAVANBAKHSHIAN, REYHANEH, & BEHBAHANI, MANDANA. (2018). CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF FERMENTED AND NON-FERMENTED EXTRACTS OF GARLIC. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(156 ), 38-49. SID. https://sid.ir/paper/44713/en

Vancouver: Copy

RAVANBAKHSHIAN REYHANEH, BEHBAHANI MANDANA. CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF FERMENTED AND NON-FERMENTED EXTRACTS OF GARLIC. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(156 ):38-49. Available from: https://sid.ir/paper/44713/en

IEEE: Copy

REYHANEH RAVANBAKHSHIAN, and MANDANA BEHBAHANI, “CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF FERMENTED AND NON-FERMENTED EXTRACTS OF GARLIC,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 156 , pp. 38–49, 2018, [Online]. Available: https://sid.ir/paper/44713/en

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