EVALUATION OF PROTECTIVE EFFECT OF VITAMINS E, C AND A ON SUPEROXIDE DISMUTASE ENZYME ACTIVITY IN RAT ERYTHROCYTES EXPOSED TO DIAZINON

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SHOKRZADEH MOHAMMAD; HOSSEINI PAYAM SAKINE SADAT; ZARGARI MEHRYAR; ABASI ALI; ABEDIAN SAEED; LAYALI ISA; SHADBORESTAN AMIR; OMIDI MAHMOOD; AHMADI BASIRI ELHAM

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:21 | Issue:SUPPLEMENT 1 Page(s): 31-39

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Title

EVALUATION OF PROTECTIVE EFFECT OF VITAMINS E, C AND A ON SUPEROXIDE DISMUTASE ENZYME ACTIVITY IN RAT ERYTHROCYTES EXPOSED TO DIAZINON

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Keywords

DIAZINONQ2

SUPEROXIDE DISMUTASEQ2

OXIDATIVE STRESSQ2

VITAMIN EQ2

CQ2

AQ2

Abstract

Background And purpose: Organophosphate insecticides Are major groups of Chemical pesticides which is used for pest Control in the Agricultural fields, gardens. DIAZINON is An important oreganophosphate insecticides easily Absorbed through intestine, respiratory system And skin. It is metabolized in the liver to An Active metabolite: Diazoxon. The purpose of this study was to examine the protective effect of vitamien E, C And A on SUPEROXIDE DISMUTASE enzyme Activity in rat erythrocyte exposed to DIAZINON.Materials And methods: In this study, male Wistar rats were divided into 9 groups. The groups were Administered Normal Saline, soybean oil (as the solvent DIAZINON And fat-soluble vitamins), DIAZINON (30 mg/kg), vitamins E, C, A (respectively 100 mg/kg, 500 mg/kg, 400 IU/kg) And Combination of DIAZINON with the some dose of each vitamins intraperitoneally (IP) for 14 days.7 days After the last injection, the Animals were Anesthetized And 1 ml of blood was taken from the rat heart. Blood was spinned And erythrocytes was Aspirated And lysate, hemolysis prepared for SUPEROXIDE DISMUTASE enzyme Activity was measured. Data Analysis using statistical software spss test And Kruskal-Wallis And Mann Whitney was 5% significance level (Mean ± SD).Results: The Activity of SUPEROXIDE DISMUTASE enzymes was significantly higher in the DIAZINON exposed group than of Control group (P=0.008) And. DIAZINON/vitamin group display An increased significantly of enzyme Activity than of Control group (P=0.005).Conclusion: Administration of DIAZINON increases production of superoxide radicals followed by An increase in SUPEROXIDE DISMUTASE enzyme Activity this indicated OXIDATIVE STRESS to be An Associated mechanism involved in dizinin toxicitycan. Administartion of Vitamnin C, E, And A slightly Attenuate the toxic effect of DIAZINON on rat reythrocye.

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APA: Copy

SHOKRZADEH, MOHAMMAD, HOSSEINI PAYAM, SAKINE SADAT, ZARGARI, MEHRYAR, ABASI, ALI, ABEDIAN, SAEED, LAYALI, ISA, SHADBORESTAN, AMIR, OMIDI, MAHMOOD, & AHMADI BASIRI, ELHAM. (2012). EVALUATION OF PROTECTIVE EFFECT OF VITAMINS E, C AND A ON SUPEROXIDE DISMUTASE ENZYME ACTIVITY IN RAT ERYTHROCYTES EXPOSED TO DIAZINON. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 21(SUPPLEMENT 1), 31-39. SID. https://sid.ir/paper/44743/en

Vancouver: Copy

SHOKRZADEH MOHAMMAD, HOSSEINI PAYAM SAKINE SADAT, ZARGARI MEHRYAR, ABASI ALI, ABEDIAN SAEED, LAYALI ISA, SHADBORESTAN AMIR, OMIDI MAHMOOD, AHMADI BASIRI ELHAM. EVALUATION OF PROTECTIVE EFFECT OF VITAMINS E, C AND A ON SUPEROXIDE DISMUTASE ENZYME ACTIVITY IN RAT ERYTHROCYTES EXPOSED TO DIAZINON. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;21(SUPPLEMENT 1):31-39. Available from: https://sid.ir/paper/44743/en

IEEE: Copy

MOHAMMAD SHOKRZADEH, SAKINE SADAT HOSSEINI PAYAM, MEHRYAR ZARGARI, ALI ABASI, SAEED ABEDIAN, ISA LAYALI, AMIR SHADBORESTAN, MAHMOOD OMIDI, and ELHAM AHMADI BASIRI, “EVALUATION OF PROTECTIVE EFFECT OF VITAMINS E, C AND A ON SUPEROXIDE DISMUTASE ENZYME ACTIVITY IN RAT ERYTHROCYTES EXPOSED TO DIAZINON,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. SUPPLEMENT 1, pp. 31–39, 2012, [Online]. Available: https://sid.ir/paper/44743/en

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