ASSOCIATION BETWEEN POLYMORPHISM OF FAS/CD59 AND GASTRIC ADENOCARCINOMA

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FAZLI BAHMAN; HOSSEINI VAHID; HOSSEINI KHAH ZAHRA; AJAMI ABULGHASEM; RAFIEI ALIREZA; JANBABAI GHASEM; EMADIAN OMID

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:21 | Issue:SUPPLEMENT 1 Page(s): 310-317

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Title

ASSOCIATION BETWEEN POLYMORPHISM OF FAS/CD59 AND GASTRIC ADENOCARCINOMA

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Keywords

GASTRIC CANCERQ2

RFLP-PCRQ2

FAS-670 POLYMORPHISMQ2

APOPTOSISQ2

Abstract

Background and purpose: APOPTOSIS is a physiological mechanism of program cell death so that dysregulation in this process may lead to carcinogenesis. Functional gene polymorphism in Fas can alter transcriptional activities and thus change risk of cancer. A to G substitution in Fas -670 promoter region disrupts the binding site of STAT1 transcription factor. This study aimed to assess the association of genetic variants of Fas –A670G polymorphism and the potential risk of GASTRIC CANCER.Materials and methods: Genomic DNA was extracted from 159 patients with gastric adenocarcinoma and 170 age, sex and ethnic background matched healthy controls. GASTRIC CANCER was diagnosed based on clinical and endoscopic findings, and pathologically confirmed. Genotyping was done PCR-RFLP method. Odds ratios and 95% confidence intervals were obtained from logistic regression models adjusted for potential confounding factors.Results: The distribution of allele frequency in the patients and controls was not meet significantly (58.6% vs. 61.8%, p=0.47). Meanwhile, the genotype frequencies of –A670G polymorphism were significantly differed in to groups. The A/G heterozygosity was less frequent in the patients than that controls (42.4% vs.51.8%, p=0.041). On the other hand, the presence of heterozygous A670G was decreased the cancer risk les than 0.5 (95% CI; 0.26-0.94).Conclusion: Conclusion: Our findings indicated that A670G polymorphism in Fas promoter region might be associated to the risk of GASTRIC CANCER. Therefore, genetic variation in Fas/FasL system due to corruption in apoptotic process may contribute to etiology.

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APA: Copy

FAZLI, BAHMAN, HOSSEINI, VAHID, HOSSEINI KHAH, ZAHRA, AJAMI, ABULGHASEM, RAFIEI, ALIREZA, JANBABAI, GHASEM, & EMADIAN, OMID. (2012). ASSOCIATION BETWEEN POLYMORPHISM OF FAS/CD59 AND GASTRIC ADENOCARCINOMA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 21(SUPPLEMENT 1), 310-317. SID. https://sid.ir/paper/44758/en

Vancouver: Copy

FAZLI BAHMAN, HOSSEINI VAHID, HOSSEINI KHAH ZAHRA, AJAMI ABULGHASEM, RAFIEI ALIREZA, JANBABAI GHASEM, EMADIAN OMID. ASSOCIATION BETWEEN POLYMORPHISM OF FAS/CD59 AND GASTRIC ADENOCARCINOMA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;21(SUPPLEMENT 1):310-317. Available from: https://sid.ir/paper/44758/en

IEEE: Copy

BAHMAN FAZLI, VAHID HOSSEINI, ZAHRA HOSSEINI KHAH, ABULGHASEM AJAMI, ALIREZA RAFIEI, GHASEM JANBABAI, and OMID EMADIAN, “ASSOCIATION BETWEEN POLYMORPHISM OF FAS/CD59 AND GASTRIC ADENOCARCINOMA,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. SUPPLEMENT 1, pp. 310–317, 2012, [Online]. Available: https://sid.ir/paper/44758/en

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