ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE PROPERTIES OF FRACTIONATED EXTRACTS IN DIFFERENT PARTS OF SAMBUCUS EBULUS

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EBRAHIMIZADEH M.A.; MAHMOUDI M.; POURMORAD F.; SAEIDNIA S.; SALIMI E.

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Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2006 | Volume:16 | Issue:54 Page(s): 35-42

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Title

ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE PROPERTIES OF FRACTIONATED EXTRACTS IN DIFFERENT PARTS OF SAMBUCUS EBULUS

Author(s)

Keywords

ANALGESICQ3

WRITHING TESTQ3

HOTPLATEQ3

ANTI-INFLAMMATORY ACTIVITYQ2

CARRAGEENANQ2

SAMBUCUS EBULUSQ2

Abstract

Background and purpose: In Iranian folk medicine, the leaves and rhizomes of the plant SAMBUCUS EBULUS have been used topically for curing painful joint diseases. This study was undertaken to evaluate the anti-inflammatory and antinociceptive efficacy of different parts of SAMBUCUS EBULUS in mice and rats.Materials and Methods: Different parts of SAMBUCUS EBULUS were collected from Sari. Fruits, leaves and roots were fractionated by successive solvent extraction with hexane, ethyl acetate and finally methanol. Anti-nociceptive and anti-inflammatory activities of extracts were determined using hot plate, writhing and CARRAGEENAN-induced inflammation tests in mice and rats respectively.Results: Nearly all extracts showed a dose dependent and marked ANALGESIC and anti-inflammatory activities when compared to the control. Only hexane extract of leaves did not show any ANTI-INFLAMMATORY ACTIVITY up to 600 mg/kg i.p. Hexane extract possessed significantly higher activity than methanol extract. Ethyl acetate extract were withdrawn because of severe nociceptive response in mice. No extracts exhibited any toxicity up to 2 g/ kg body weight intraperitoneally in mice for one week.Conclusion: The results of the present study support the folkloric utilization of this herb. Hexane extract of fruits showed highest ANALGESIC and anti-inflammatory activities. Phytochemical analysis, the elucidation of exact mechanism of action and active components responsible for the hypernociceptive effect of ethyl acetate extract requires further investigations.

Cites

THE STUDY OF TYHE ESSENTIAL OIL COMPONENTS OF LEAVES AND FLOWERS OF SAMBUCUS EBULUS L. GROWING WILD IN IRAN

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APA: Copy

EBRAHIMIZADEH, M.A., MAHMOUDI, M., POURMORAD, F., SAEIDNIA, S., & SALIMI, E.. (2006). ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE PROPERTIES OF FRACTIONATED EXTRACTS IN DIFFERENT PARTS OF SAMBUCUS EBULUS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 16(54), 35-42. SID. https://sid.ir/paper/44843/en

Vancouver: Copy

EBRAHIMIZADEH M.A., MAHMOUDI M., POURMORAD F., SAEIDNIA S., SALIMI E.. ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE PROPERTIES OF FRACTIONATED EXTRACTS IN DIFFERENT PARTS OF SAMBUCUS EBULUS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;16(54):35-42. Available from: https://sid.ir/paper/44843/en

IEEE: Copy

M.A. EBRAHIMIZADEH, M. MAHMOUDI, F. POURMORAD, S. SAEIDNIA, and E. SALIMI, “ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE PROPERTIES OF FRACTIONATED EXTRACTS IN DIFFERENT PARTS OF SAMBUCUS EBULUS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 54, pp. 35–42, 2006, [Online]. Available: https://sid.ir/paper/44843/en

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