Effects of Crocin on Oxidative Stress Indices in Rat Brain Demylated with Ethidium Bromide

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Fathi Moghadam Hadi; Farbod Yagoub; Ghadiri Ata A.; Fatemi Rohallah

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Journal: Journal of Mazandaran University of Medical Sciences Year:2019 | Volume:29 | Issue:172 Page(s): 121-126

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Title

Effects of Crocin on Oxidative Stress Indices in Rat Brain Demylated with Ethidium Bromide

Author(s)

Fathi Moghadam Hadi | Farbod Yagoub | Ghadiri Ata A. | Fatemi Rohallah | Issue Writer Certificate

Keywords

demyelinationQ2

oxidative stressQ2

crocinQ1

malondialdehydeQ2

superoxide dismutaseQ2

Abstract

Background and purpose: The purpose of this study was to investigate the effects of crocin (Cr) on brain oxidative stress indices in animal model demyelinated with intracerebroventricular ethidium bromide (EB). Materials and methods: In an interventional study, female Wistar rats were randomly divided into 7 groups. crocin administration was done 1 day after EB injection for 21 days. The values for Glutathione peroxidase (GPx), superoxide dismutase (SOD), and malondialdehyde (MDA) were measured before and after receiving Cr and analyzed using Paired t test and ANOVA. Results: The levels of GPx, SOD, and MDA significantly reduced in the group that received Cr100 mg/kg (P<0. 05). The effects of crocin were dose-dependent and other doses did not demonstrate significant effects on oxidative stress indices (P< 0. 05). Conclusion: The antioxidant effects of crocin were dose-dependent, and it could be used as a strong antioxidant in management of patients with multiple sclerosis.

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APA: Copy

Fathi Moghadam, Hadi, Farbod, Yagoub, Ghadiri, Ata A., & Fatemi, Rohallah. (2019). Effects of Crocin on Oxidative Stress Indices in Rat Brain Demylated with Ethidium Bromide. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(172 ), 121-126. SID. https://sid.ir/paper/44958/en

Vancouver: Copy

Fathi Moghadam Hadi, Farbod Yagoub, Ghadiri Ata A., Fatemi Rohallah. Effects of Crocin on Oxidative Stress Indices in Rat Brain Demylated with Ethidium Bromide. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;29(172 ):121-126. Available from: https://sid.ir/paper/44958/en

IEEE: Copy

Hadi Fathi Moghadam, Yagoub Farbod, Ata A. Ghadiri, and Rohallah Fatemi, “Effects of Crocin on Oxidative Stress Indices in Rat Brain Demylated with Ethidium Bromide,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 172 , pp. 121–126, 2019, [Online]. Available: https://sid.ir/paper/44958/en

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