INVESTIGATING THE EFFECT OF MIXED SURFACTANTS WITH DIFFERENTHLBS ON THE PROPERTIES OF SOLID LIPID NANOPARTICLE OFSPIRONOLACTONE

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IMANI ZHILA; SAEEDI MAJID; AKBARI JAFAR; MORTEZA SEMNANI KATAYOUN; IMANI ZAHRA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:162 Page(s): 37-46

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Title

INVESTIGATING THE EFFECT OF MIXED SURFACTANTS WITH DIFFERENTHLBS ON THE PROPERTIES OF SOLID LIPID NANOPARTICLE OFSPIRONOLACTONE

Author(s)

Keywords

SOLID LIPID NANOPARTICLESQ1

SPIRONOLACTONEQ2

TWEEN 80Q2

PALMITIC ACIDQ1

SPAN 60Q1

Abstract

Background and purpose: This study investigated the effect of different HLBs on thesenanoparticles using SPIRONOLACTONE SOLID LIPID NANOPARTICLES. Materials and methods: The SPIRONOLACTONE loaded SLN was prepared by emulsion/solventevaporation technique followed by ultrasonication. In this study, PALMITIC ACID was used as carrier. Different weight ratio of drug, carrier, Span60 and Tween80 were selected. Different formulations wereprepared with different HLBs. Nanoparticle properties like particle size, polydispersity index, zetapotential and entrapment efficiency were investigated. Optimum formulation was chosen for evaluation ofdrug release and other properties of nanoparticles by DSC and FT-IR spectroscopy. Results: Increasing lipid concentration resulted in consequent increase entrapment efficiency andthe size. Also, the F1-F9 formulations showed that Zeta potential was in an acceptable range, and onlyreduce in HLB in F4 was accompanied with decreasing Zeta potential. SPIRONOLACTONE was found to havea higher drug release rate in the SLN form. Information from the FT-IR spectroscopy and the DSCthermogram indicated effective entrapment of drug in the carrier. Conclusion: SPIRONOLACTONE-SLNs provide a controlled and increased drug release rates. Spironolacton-SLN would provide high drug levels at the site of action, therefore, this product could beuseful in topical drug delivery.

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APA: Copy

IMANI, ZHILA, SAEEDI, MAJID, AKBARI, JAFAR, MORTEZA SEMNANI, KATAYOUN, & IMANI, ZAHRA. (2018). INVESTIGATING THE EFFECT OF MIXED SURFACTANTS WITH DIFFERENTHLBS ON THE PROPERTIES OF SOLID LIPID NANOPARTICLE OFSPIRONOLACTONE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(162 ), 37-46. SID. https://sid.ir/paper/45049/en

Vancouver: Copy

IMANI ZHILA, SAEEDI MAJID, AKBARI JAFAR, MORTEZA SEMNANI KATAYOUN, IMANI ZAHRA. INVESTIGATING THE EFFECT OF MIXED SURFACTANTS WITH DIFFERENTHLBS ON THE PROPERTIES OF SOLID LIPID NANOPARTICLE OFSPIRONOLACTONE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(162 ):37-46. Available from: https://sid.ir/paper/45049/en

IEEE: Copy

ZHILA IMANI, MAJID SAEEDI, JAFAR AKBARI, KATAYOUN MORTEZA SEMNANI, and ZAHRA IMANI, “INVESTIGATING THE EFFECT OF MIXED SURFACTANTS WITH DIFFERENTHLBS ON THE PROPERTIES OF SOLID LIPID NANOPARTICLE OFSPIRONOLACTONE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 162 , pp. 37–46, 2018, [Online]. Available: https://sid.ir/paper/45049/en

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