INVESTIGATING THE EFFECT OF COATED LIPID NANO PARTICLES OF SPIRONOLACTONE WITH CHITOSAN ON THEIR PROPERTIES

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ENAYATIFARD REZA; AKBARI JAFAR; SAEEDI MAJID; MORTEZA SEMNANI KATAYOUN; PARVIN SAFIEH; HASHEMI SEYYED MOHAMMAD HASSAN; BABAEI AMIRHOSSEIN; ROSTAMKALAEI SEYYED SOHRAB

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:162 Page(s): 25-36

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Title

INVESTIGATING THE EFFECT OF COATED LIPID NANO PARTICLES OF SPIRONOLACTONE WITH CHITOSAN ON THEIR PROPERTIES

Author(s)

Keywords

SOLID LIPID NANOPARTICLESQ1

SPIRONOLACTONEQ2

TWEEN 20Q1

SPAN 80Q1

Abstract

Background and purpose: SOLID LIPID NANOPARTICLES are in the colloid carriers. The benefits ofthese drug carriers are the controlled release of the drug and the protection of the drug being loaded. SPIRONOLACTONE is an aldosterone antagonist and androgen receptor. Its oral bioavailability is low due tothe low solubility of this drug and its slow release. Reducing particle size by increasing the level of thedrug leads to increased release, higher oral bioavailability, higher particle size in contact with thedissolution medium, and increasing the dissolvability of the drug saturation. Materials and methods: Solvent emulsification/evaporation was used to preparespironolactone nanoparticles. For this purpose, the lipid and drug were dissolved in an appropriateorganic solvent and added to the aqueous phase containing surfactant during mixing by homogenizer. After coated with chitosan, the chitosan was dissolved in dilute acid and was added to the suspension onthe stirrer drop by drop. Results: By maintaining the amount of lipid in the formulation and increasing the amount ofsurfactant, the particle size decreased significantly. In general, the coating of SPIRONOLACTONE nanoparticleswith chitosan increased the particle size and their dispersion, and the zeta potential changed from anegative value to a positive value. Conclusion: SPIRONOLACTONE coated with chitosan was found to have a slower release than solidlipid nanoparticles and nanosuspension.

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APA: Copy

ENAYATIFARD, REZA, AKBARI, JAFAR, SAEEDI, MAJID, MORTEZA SEMNANI, KATAYOUN, PARVIN, SAFIEH, HASHEMI, SEYYED MOHAMMAD HASSAN, BABAEI, AMIRHOSSEIN, & ROSTAMKALAEI, SEYYED SOHRAB. (2018). INVESTIGATING THE EFFECT OF COATED LIPID NANO PARTICLES OF SPIRONOLACTONE WITH CHITOSAN ON THEIR PROPERTIES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(162 ), 25-36. SID. https://sid.ir/paper/45040/en

Vancouver: Copy

ENAYATIFARD REZA, AKBARI JAFAR, SAEEDI MAJID, MORTEZA SEMNANI KATAYOUN, PARVIN SAFIEH, HASHEMI SEYYED MOHAMMAD HASSAN, BABAEI AMIRHOSSEIN, ROSTAMKALAEI SEYYED SOHRAB. INVESTIGATING THE EFFECT OF COATED LIPID NANO PARTICLES OF SPIRONOLACTONE WITH CHITOSAN ON THEIR PROPERTIES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(162 ):25-36. Available from: https://sid.ir/paper/45040/en

IEEE: Copy

REZA ENAYATIFARD, JAFAR AKBARI, MAJID SAEEDI, KATAYOUN MORTEZA SEMNANI, SAFIEH PARVIN, SEYYED MOHAMMAD HASSAN HASHEMI, AMIRHOSSEIN BABAEI, and SEYYED SOHRAB ROSTAMKALAEI, “INVESTIGATING THE EFFECT OF COATED LIPID NANO PARTICLES OF SPIRONOLACTONE WITH CHITOSAN ON THEIR PROPERTIES,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 162 , pp. 25–36, 2018, [Online]. Available: https://sid.ir/paper/45040/en

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