POLYMORPHISMS OF CYP1A1 GENE VARIANTS M1 AND M2 AND THEIR ASSOCIATION WITH THE INCIDENCE OF CANCER IN WEST OF MAZANDARAN PROVINCE, IRAN

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HOSSEINI SABA SADAT; KEYHANIAN SHAHRBANOU; VOSOUGHI EBRAHIM; AHANGAR NEMATOLLAH

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:165 Page(s): 57-68

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Title

POLYMORPHISMS OF CYP1A1 GENE VARIANTS M1 AND M2 AND THEIR ASSOCIATION WITH THE INCIDENCE OF CANCER IN WEST OF MAZANDARAN PROVINCE, IRAN

Author(s)

HOSSEINI SABA SADAT | KEYHANIAN SHAHRBANOU | VOSOUGHI EBRAHIM | AHANGAR NEMATOLLAH | Issue Writer Certificate

Keywords

CYP 1A1Q2

IRANIAN POPULATIONQ3

MAZANDARANQ1

POLYMORPHISMQ1

PCR-RFLPQ1

Abstract

Background and purpose: The aim of this study was to determine the genetic variability ofCYP1A1 m1 and m2 POLYMORPHISMs in cancer patients compared with healthy population in the west ofMazandaran province, Iran. Materials and methods: A case-control study was carried out in 120 non-relative healthyvolunteers (60 males and 60 females) and 84 non-relative patients (39 males and 46 females) withdiagnosis of cancer, attending the Hematology/Oncology ward in Ramsar Imam Sajjad Hospital between July2016 and December 2017. Peripheral blood samples (3ml) were taken from the participants and stored at-20° C. The PCR-RFLP method was used to determine the distribution of CYP1A1 gene POLYMORPHISMs. Results: Among the two gene variants m1 and m2, individuals with AG and GG genotypes ofCYP1A1 m2 POLYMORPHISM were found to have a significantly higher and increased risk for cancer(OR=3. 94, 95%CI=2. 05-7. 57, P= 0. 00, OR=9. 46, 95%CI=1. 92-46. 49, P= 0. 00, respectively) and the TCgenotype of CYP1A1 m1 POLYMORPHISM also had a significantly higher and increased risk for cancer(OR= 2. 6, 95% CI = 1. 4-4. 6, P=0. 00). The ‘ G’ allele was detected to have a strong association withcancer (P<0. 001). The ‘ C’ allele also showed strong association with the incidence of cancer (P<0. 001). Thus, both CYP1A1 m1 and m2 POLYMORPHISMs showed an increased risk for cancer. Conclusion: Our study suggested that the presence of ‘ C’ allele of m1 POLYMORPHISM and ‘ G’ allele of m2 POLYMORPHISM as the leading alleles that increase cancer susceptibility in the studiedpopulation.

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APA: Copy

HOSSEINI, SABA SADAT, KEYHANIAN, SHAHRBANOU, VOSOUGHI, EBRAHIM, & AHANGAR, NEMATOLLAH. (2018). POLYMORPHISMS OF CYP1A1 GENE VARIANTS M1 AND M2 AND THEIR ASSOCIATION WITH THE INCIDENCE OF CANCER IN WEST OF MAZANDARAN PROVINCE, IRAN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(165 ), 57-68. SID. https://sid.ir/paper/45357/en

Vancouver: Copy

HOSSEINI SABA SADAT, KEYHANIAN SHAHRBANOU, VOSOUGHI EBRAHIM, AHANGAR NEMATOLLAH. POLYMORPHISMS OF CYP1A1 GENE VARIANTS M1 AND M2 AND THEIR ASSOCIATION WITH THE INCIDENCE OF CANCER IN WEST OF MAZANDARAN PROVINCE, IRAN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(165 ):57-68. Available from: https://sid.ir/paper/45357/en

IEEE: Copy

SABA SADAT HOSSEINI, SHAHRBANOU KEYHANIAN, EBRAHIM VOSOUGHI, and NEMATOLLAH AHANGAR, “POLYMORPHISMS OF CYP1A1 GENE VARIANTS M1 AND M2 AND THEIR ASSOCIATION WITH THE INCIDENCE OF CANCER IN WEST OF MAZANDARAN PROVINCE, IRAN,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 165 , pp. 57–68, 2018, [Online]. Available: https://sid.ir/paper/45357/en

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