FREQUENCY OF *4 ALLELE IN CYP2D6 GENE AND ITS ASSOCIATION WITH OVARIAN CANCER RISK IN TEHRAN, IRAN

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HELALAT SH.; ONSORY KH.; HAJI MEHDI NOURI Z.

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Journal: Armaghane Danesh Year:2016 | Volume:21 | Issue:2 (109) Page(s): 200-211

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Title

FREQUENCY OF *4 ALLELE IN CYP2D6 GENE AND ITS ASSOCIATION WITH OVARIAN CANCER RISK IN TEHRAN, IRAN

Author(s)

HELALAT SH. | ONSORY KH. | HAJI MEHDI NOURI Z. | Issue Writer Certificate

Keywords

CYP2D6*4 ALLELEQ1

POLYMORPHISMQ2

OVARIAN CANCERQ2

PCR-RFLPQ2

Abstract

Background & aim: CYP2D6 enzyme is one of the most important members of the cytochrome P450 superfamily which play an important role in the metabolism of many drugs. The CYP2D6 gene presents a high allele heterogeneity that significantly stimulated many changes between individuals in a population, so that classified into extensive, intermediate, or poor drug metabolizers. The CYP2D6*4 allele is the most common polymorphic allele of CYP2D6 gene which due to a nucleotide change of G→A (G1934→A), resulting in a reduced or lack of activity of CYP iso-enzyme. The aim of this study was to evaluate the frequency of CYP2D6*4 allele among patient and control groups and to find out the relationship of this POLYMORPHISM with the risk of OVARIAN CANCER patients in Tehran.Methods: In the present case-control study, samples were collected in tubes containing EDTA. DNA is extracted from cancer tissue and blood controls group were performed. The frequency of CYP2D6*4 allele was determined among 120 patients who were admitted to Imam Khomeini Hospital by PCR-RFLP method and then compared with 125 normal controls who visited the same center. The collected data were analyzed using logistic regression analysis.Results: The results show that the prevalence of patients group with poor metabolism of drugs (PM) 13.3%, heterozygotes extensive metabolizer (HEM) 23.3% and extensive metabolizer (EM) was 63.3% respectively. The results indicated no significant association was seen between HEM and OVARIAN CANCER risk (OR=1.27; CI 95% ; 2.85-0.56; P=0.55). Also no association was observed between PM and risk of this disease among the studied population (OR=0.75; CI 95%; 1.38-0.41; P= 0.36).Conclusion: There was no meaningful association between CYP2D6*4 allele which results in variations of G1934→A genetic POLYMORPHISM and OVARIAN CANCER has been observed in the study population.

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APA: Copy

HELALAT, SH., ONSORY, KH., & HAJI MEHDI NOURI, Z.. (2016). FREQUENCY OF *4 ALLELE IN CYP2D6 GENE AND ITS ASSOCIATION WITH OVARIAN CANCER RISK IN TEHRAN, IRAN. ARMAGHAN DANESH, 21(2 (109)), 200-211. SID. https://sid.ir/paper/78132/en

Vancouver: Copy

HELALAT SH., ONSORY KH., HAJI MEHDI NOURI Z.. FREQUENCY OF *4 ALLELE IN CYP2D6 GENE AND ITS ASSOCIATION WITH OVARIAN CANCER RISK IN TEHRAN, IRAN. ARMAGHAN DANESH[Internet]. 2016;21(2 (109)):200-211. Available from: https://sid.ir/paper/78132/en

IEEE: Copy

SH. HELALAT, KH. ONSORY, and Z. HAJI MEHDI NOURI, “FREQUENCY OF *4 ALLELE IN CYP2D6 GENE AND ITS ASSOCIATION WITH OVARIAN CANCER RISK IN TEHRAN, IRAN,” ARMAGHAN DANESH, vol. 21, no. 2 (109), pp. 200–211, 2016, [Online]. Available: https://sid.ir/paper/78132/en

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