UP REGULATION OF CD82 GENE IN PROSTATE CANCER PC-3 CELL LINE TREATED WITH SILIBININ

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MOKHTARI M.J.; SHOKRGOZAR M.A.; MOTAMED N.; AKBARZADEH A.; MOUMENI MAJID; KAMIAB A.R.; EDALAT R.; AZARI SH.; AMANZADEH A.

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Journal: Pathobiology Research Year:2010 | Volume:13 | Issue:3 Page(s): 41-52

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Title

UP REGULATION OF CD82 GENE IN PROSTATE CANCER PC-3 CELL LINE TREATED WITH SILIBININ

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Keywords

SILIBININQ3

CD82Q3

PROSTATE CANCERQ2

METASTASISQ3

REAL-TIME PCRQ2

Abstract

Objective: PROSTATE CANCER is one of the most common cancer in the developed countries. Most of cancer deaths are due to development of METASTASIS. Hence, prevention of METASTASIS is critical. SILIBININ is a flavonoid component that inhibits cell proliferation and causes cell death of human PROSTATE CANCER. In this study, the expression of CD82 gene in PC-3 cells treated with escalating concentrations of SILIBININ was evaluated which can result in new view for PROSTATE CANCER therapy.Materials and Methods: In this study, PC-3 cells were treated with different concentrations of SILIBININ for 24h. The LD50 was determined. RNA was extracted by trizol, and then cDNA was synthesized. Precise primers were designed for CD82 and GAPDH genes by specific software. Quantity of CD82 gene expression compare to GAPDH gene in different concentrations of silibilin was analyzed using very sensitive quantitative REAL-TIME PCR.Results: CD82 gene expression in PC-3 cells treated with 100, 150 and 200 mg/ml of SILIBININ at 24h was increased by 1.97±0.26 (P<0.05), 3.00±0.26 and 3.43±0.43 (P<0.01), respectively.Conclusion: The results of quantitative REAL-TIME PCR indicated that SILIBININ can probably decrease METASTASIS, by up-regulation of CD82 METASTASIS suppressor gene in PC-3 cells.

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APA: Copy

MOKHTARI, M.J., SHOKRGOZAR, M.A., MOTAMED, N., AKBARZADEH, A., MOUMENI, MAJID, KAMIAB, A.R., EDALAT, R., AZARI, SH., & AMANZADEH, A.. (2010). UP REGULATION OF CD₈₂ GENE IN PROSTATE CANCER PC-3 CELL LINE TREATED WITH SILIBININ. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 13(3), 41-52. SID. https://sid.ir/paper/81218/en

Vancouver: Copy

MOKHTARI M.J., SHOKRGOZAR M.A., MOTAMED N., AKBARZADEH A., MOUMENI MAJID, KAMIAB A.R., EDALAT R., AZARI SH., AMANZADEH A.. UP REGULATION OF CD₈₂ GENE IN PROSTATE CANCER PC-3 CELL LINE TREATED WITH SILIBININ. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2010;13(3):41-52. Available from: https://sid.ir/paper/81218/en

IEEE: Copy

M.J. MOKHTARI, M.A. SHOKRGOZAR, N. MOTAMED, A. AKBARZADEH, MAJID MOUMENI, A.R. KAMIAB, R. EDALAT, SH. AZARI, and A. AMANZADEH, “UP REGULATION OF CD₈₂ GENE IN PROSTATE CANCER PC-3 CELL LINE TREATED WITH SILIBININ,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 13, no. 3, pp. 41–52, 2010, [Online]. Available: https://sid.ir/paper/81218/en

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