ORGANOPHOSPHORUS COMPOUNDS AND BRAIN GABAERGIC SYSTEM

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ZARE ZOHRE; MOHAMMADI MOSLEM

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:27 | Issue:155 Page(s): 210-224

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Title

ORGANOPHOSPHORUS COMPOUNDS AND BRAIN GABAERGIC SYSTEM

Author(s)

ZARE ZOHRE | MOHAMMADI MOSLEM | Issue Writer Certificate

Keywords

ORGANOPHOSPHORUS COMPOUNDSQ1

GAMMA-AMINOBUTYRIC ACIDQ1

ACETYLCHOLINESTERASEQ2

SEIZUREQ1

Abstract

Organophosphorus (OP) compounds are cholinesterase inhibitors widely used as pesticides in agriculture and nerve agents in battlefields. Exposure to these compounds leads to accumulation of acetylcholine at cholinergic synapses and overstimulation of muscarinic and nicotinic receptors by inhibiting the enzyme ACETYLCHOLINESTERASE. SEIZURE activity is one of the major manifestations of OP poisoning that is produced as a result of hyperstimulation of brain muscarinic receptors and subsequent recruitment of other neurotransmitter systems. Disruption of the excitatory/inhibitory balance can lead to OP-induced SEIZURE activity and subsequent brain damages.Gamma -aminobutyric acid (GABA), the main inhibitory neurotransmitter in mammalian central nervous system, is synthesized from glutamate by glutamic acid decarboxylase and modulates neuronal excitability. After release, GABA binds to two different types of receptors: ionotrpic (GABAA and GABAC) and metabotropic (GABAB) receptors.Drugs that enhance GABAA-mediated inhibition are effective in treatment of OP-induced SEIZUREs. There is discrepancy in the literatures regarding changes on brain GABAergic system during OP intoxication.This review discusses the mechanism and toxic effects of OP compounds, brain GABAergic system, and how it changes following exposure to OP compounds.

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APA: Copy

ZARE, ZOHRE, & MOHAMMADI, MOSLEM. (2017). ORGANOPHOSPHORUS COMPOUNDS AND BRAIN GABAERGIC SYSTEM. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(155 ), 210-224. SID. https://sid.ir/paper/45511/en

Vancouver: Copy

ZARE ZOHRE, MOHAMMADI MOSLEM. ORGANOPHOSPHORUS COMPOUNDS AND BRAIN GABAERGIC SYSTEM. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;27(155 ):210-224. Available from: https://sid.ir/paper/45511/en

IEEE: Copy

ZOHRE ZARE, and MOSLEM MOHAMMADI, “ORGANOPHOSPHORUS COMPOUNDS AND BRAIN GABAERGIC SYSTEM,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 155 , pp. 210–224, 2017, [Online]. Available: https://sid.ir/paper/45511/en

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