EVALUATION OF MIR-126 RS4636297 GENE POLYMORPHISM IN INFERTILE WOMEN WITH ENDOMETRIOSIS

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SEPAHI HOSSEIN ABADI NEDA; KOHAN LEILA; RASEKH JAHROMI ATHAR

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Journal: Journal of Mazandaran University of Medical Sciences Year:2016 | Volume:26 | Issue:141 Page(s): 1-7

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Title

EVALUATION OF MIR-126 RS4636297 GENE POLYMORPHISM IN INFERTILE WOMEN WITH ENDOMETRIOSIS

Author(s)

SEPAHI HOSSEIN ABADI NEDA | KOHAN LEILA | RASEKH JAHROMI ATHAR | Issue Writer Certificate

Keywords

ENDOMETRIOSISQ2

INFERTILITYQ2

MIR-126Q1

POLYMORPHISMQ2

Abstract

Background and purpose: ENDOMETRIOSIS is a benign disorder defined by the presence of endometrial tissue out of pelvic cavity and is related to debilitating pelvic pain and INFERTILITY. MiRNAs, are a cluster of small endogenous noncoding RNA that bind to 3׳ UTR of target mRNA and cause mRNA degradation or repressing translation of mRNA. MIR-126 is a type of miRNA that is involved in many vital processes such as invasion and angiogenesis. In this study, MIR-126 rs4636297 G/A gene POLYMORPHISM was compared between infertile women with ENDOMETRIOSIS and healthy women.Materials and methods: This analytical study was done in 72 infertile women with ENDOMETRIOSIS and 252 healthy women as a control group. After extraction of genomic DNA from peripheral blood samples, desired POLYMORPHISM was genotyped using Tetra-ARMS-PCR method.Statistical analysis was performed using SPSS ver.17. Genotype distributions and allelic frequencies of MIR-126rs4636297 gene POLYMORPHISM were compared between patient and control groups by Logistic regression analysis.Results: A significant association was found between A allele of rs4636297 MIR-126 POLYMORPHISM and ENDOMETRIOSIS (OR: 0.6, 95% CI: 0.4-0.84, P=0.005). In the dominant model of A allele (comparison between AA+AG VS. GG), AA+AG had protective effect on ENDOMETRIOSIS (OR: 0.48, 95% CI: 0.28-0.82, P=0.007).Conclusion: There is a significant association between rs4636297 MIR-126 POLYMORPHISM and susceptibility to ENDOMETRIOSIS.

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APA: Copy

SEPAHI HOSSEIN ABADI, NEDA, KOHAN, LEILA, & RASEKH JAHROMI, ATHAR. (2016). EVALUATION OF MIR-126 RS4636297 GENE POLYMORPHISM IN INFERTILE WOMEN WITH ENDOMETRIOSIS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(141), 1-7. SID. https://sid.ir/paper/45621/en

Vancouver: Copy

SEPAHI HOSSEIN ABADI NEDA, KOHAN LEILA, RASEKH JAHROMI ATHAR. EVALUATION OF MIR-126 RS4636297 GENE POLYMORPHISM IN INFERTILE WOMEN WITH ENDOMETRIOSIS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(141):1-7. Available from: https://sid.ir/paper/45621/en

IEEE: Copy

NEDA SEPAHI HOSSEIN ABADI, LEILA KOHAN, and ATHAR RASEKH JAHROMI, “EVALUATION OF MIR-126 RS4636297 GENE POLYMORPHISM IN INFERTILE WOMEN WITH ENDOMETRIOSIS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 141, pp. 1–7, 2016, [Online]. Available: https://sid.ir/paper/45621/en

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