THE ASSOCIATION OF RS2910164 POLYMORPHISM IN MIR-146A GENE WITH OBESITY IN IRANIAN WOMEN

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HOSSEINI AMIR HOSSEIN; KOHAN LEILA; FALLAHI SARA

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2015 | Volume:18 | Issue:8 (101) Page(s): 27-34

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Title

THE ASSOCIATION OF RS2910164 POLYMORPHISM IN MIR-146A GENE WITH OBESITY IN IRANIAN WOMEN

Author(s)

HOSSEINI AMIR HOSSEIN | KOHAN LEILA | FALLAHI SARA | Issue Writer Certificate

Keywords

MIR-146AQ2

OBESITYQ1

OVERWEIGHTQ1

POLYMORPHISMQ2

Abstract

Background: OBESITY is a complex, multifaceted disease resulting from a combination of genetic, environmental, and lifestyle backgrounds, and is associated with increased risk of diseases, such as hypertension, dyslipidemia, and type 2 diabetes. MiRNAs have been reported to be associated with chronic diseases such as OBESITY. The present study is the first investigation that examines the possible association of rs2910164 POLYMORPHISM in MIR-146A gene with OVERWEIGHT and OBESITY in Iranian women.Materials and Methods: This case-control study was conducted on 133 OVERWEIGHT, 75 obese and 173 healthy control women with normal weight. The rs2910164 POLYMORPHISM genotypes of mir- 146a gene were determined by the Tetra-ARMS PCR method. Also, logistic regression analysis was used to estimate the association between genotypes and OBESITY risk.Results: There was a significant association between GC (OR: 1.8, 95%CI: 1-3.3, p: 0.04) and CC (OR: 4.5, 95%CI: 1.6-12.6, p: 0.004) genotypes with susceptibility to OBESITY. In the dominant genetic model of the C allele (comparison between CC+GC vs. GG), CC+GC genotypes were associated with the risk of OBESITY (OR=2.1, 95% CI: 1.2-3.7, p=0.01).Conclusion: This study showed that MIR-146A gene rs2910164 POLYMORPHISM is associated with OBESITY risk and the C allele may act as a dominant allele and increase the OBESITY risk in Iranian women.

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APA: Copy

HOSSEINI, AMIR HOSSEIN, KOHAN, LEILA, & FALLAHI, SARA. (2015). THE ASSOCIATION OF RS2910164 POLYMORPHISM IN MIR-146A GENE WITH OBESITY IN IRANIAN WOMEN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 18(8 (101)), 27-34. SID. https://sid.ir/paper/69236/en

Vancouver: Copy

HOSSEINI AMIR HOSSEIN, KOHAN LEILA, FALLAHI SARA. THE ASSOCIATION OF RS2910164 POLYMORPHISM IN MIR-146A GENE WITH OBESITY IN IRANIAN WOMEN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2015;18(8 (101)):27-34. Available from: https://sid.ir/paper/69236/en

IEEE: Copy

AMIR HOSSEIN HOSSEINI, LEILA KOHAN, and SARA FALLAHI, “THE ASSOCIATION OF RS2910164 POLYMORPHISM IN MIR-146A GENE WITH OBESITY IN IRANIAN WOMEN,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 18, no. 8 (101), pp. 27–34, 2015, [Online]. Available: https://sid.ir/paper/69236/en

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