CYTOTOXIC EFFECT OF METHANOLIC EXTRACT OF PAPAVER RHOEAS L. ON VERO CELL LINE AND ITS ANTIOXIDANT ACTIVITY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHOKRZADEH MOHAMMAD; HABIBI EMRAN; MODANLOO MONA; HESAMI SOMAYE

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:26 | Issue:145 Page(s): 364-370

Download Full-Text

Persian Verion

View:

586

Download:

Cites:

Information Journal Paper

Title

CYTOTOXIC EFFECT OF METHANOLIC EXTRACT OF PAPAVER RHOEAS L. ON VERO CELL LINE AND ITS ANTIOXIDANT ACTIVITY

Author(s)

SHOKRZADEH MOHAMMAD | HABIBI EMRAN | MODANLOO MONA | HESAMI SOMAYE | Issue Writer Certificate

Keywords

PAPAVER RHOEASQ1

CANCER CELL LINEQ1

MTT ASSAYQ2

ANTIOXIDANT ACTIVITYQ2

DPPHQ2

FRAPQ2

Abstract

Background and purpose: PAPAVER RHOEAS L (family: Papaveraceae) is commonly known as corn poppy. Recent studies have revealed that PAPAVER RHOEAS L extract has cytotoxic, genotoxic, and antioxidant effects. The present study aimed at evaluating the cytotoxic effect and ANTIOXIDANT ACTIVITY of PAPAVER RHOEAS L. methanolic extract on monkey kidney carcinoma cell lines (Vero).Materials and methods: Methanolic extract of PAPAVER RHOEAS L. was prepared by maceration method. Cultivated cell line Vero was incubated with different concentrations (0, 10, 50, 100, 500, and 1000μg/ml) of the extract for 72 hours and cell growth inhibition was determined using MTT ASSAY. The antioxidant capacity was assessed using two methods: DPPH and ferric reducing ability of plasma (FRAP). The total phenolic and flavonoid contents were also determined.Results: The IC50 of cisplatin, as a common drug, is significantly lower than that of the PAPAVER RHOEAS L. (IC50=15.96±0.26 mg/ml). Our results showed that PAPAVER RHOEAS L. extract caused a significant decree se in proliferation in monkey kidney CANCER CELL LINE (IC50=80.07 mg/ml). The scavenging effect of the extract on DPPH radical was found to be 5.74 mg/ml. The extract’s ferric reducing ability of plasma was 2.663±0.002 mg/ml. Also, the extract had more total phenolic content rather than flavonoid contents.Conclusion: This study showed that methanolic extract of PAPAVER RHOEAS L. has potent cytotoxic effect on CANCER CELL LINE Vero and considerable ANTIOXIDANT ACTIVITY. But further investigations are required to identify efficient compounds and molecular mechanism of this extract so that effective steps could be taken towards finding new drugs in treatment of diseases.

Cites

No record.

References

No record.

Cite

APA: Copy

SHOKRZADEH, MOHAMMAD, HABIBI, EMRAN, MODANLOO, MONA, & HESAMI, SOMAYE. (2017). CYTOTOXIC EFFECT OF METHANOLIC EXTRACT OF PAPAVER RHOEAS L. ON VERO CELL LINE AND ITS ANTIOXIDANT ACTIVITY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(145), 364-370. SID. https://sid.ir/paper/45776/en

Vancouver: Copy

SHOKRZADEH MOHAMMAD, HABIBI EMRAN, MODANLOO MONA, HESAMI SOMAYE. CYTOTOXIC EFFECT OF METHANOLIC EXTRACT OF PAPAVER RHOEAS L. ON VERO CELL LINE AND ITS ANTIOXIDANT ACTIVITY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;26(145):364-370. Available from: https://sid.ir/paper/45776/en

IEEE: Copy

MOHAMMAD SHOKRZADEH, EMRAN HABIBI, MONA MODANLOO, and SOMAYE HESAMI, “CYTOTOXIC EFFECT OF METHANOLIC EXTRACT OF PAPAVER RHOEAS L. ON VERO CELL LINE AND ITS ANTIOXIDANT ACTIVITY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 145, pp. 364–370, 2017, [Online]. Available: https://sid.ir/paper/45776/en

Related Journal Papers