SYNTHESIS AND IMMUNOGENISITY EVALUATION OF TETANUS TOXOID ENCAPSULATED TRIMETHYL CHITOSAN NANOPARTICLES

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GHALAVAND MAJDEDIN; SAADATI MOJTABA; SALIMIAN JAFAR; ABBASI EBRAHIM; AHMADI ALI

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:26 | Issue:145 Page(s): 54-62

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Title

SYNTHESIS AND IMMUNOGENISITY EVALUATION OF TETANUS TOXOID ENCAPSULATED TRIMETHYL CHITOSAN NANOPARTICLES

Author(s)

Keywords

NANOPARTICLESQ1

TRIMETHYL CHITOSANQ1

IMMUNIZATIONQ1

TETANUS PROTEINQ1

Abstract

Background and purpose: In recent years nanotechnology has a significant impact on various fields of human life, especially in pharmaceutical and medical needs. Some biopolymers such as chitosan which is also biocompatible are low cost and abundantly found, so, their application for vaccine production is cost benefit. TRIMETHYL CHITOSAN is a deacetylated derivative of chitosan that could be used to increase the induction of immune response. In this study, TRIMETHYL CHITOSAN NANOPARTICLES containing TETANUS PROTEIN were used to stimulate the immune system.Materials and methods: In this experimental study, synthesis of the tetanus toxoid loaded NANOPARTICLES was done by ion gelation method. Physical features of the NANOPARTICLES were investigated using scanning electron microscopy (SEM). The NANOPARTICLES were then injected subcutaneously into mice. After the sampling process, the immune system stimulation was evaluated using indirect ELISA. Data was analyzed using one-way ANOVA and significance level of P<0.05.Results: The purity of protein was confirmed by SDS-PAGE and encapsulated proteins were loaded up to 80 percent. ELISA results showed that the immune system was stimulated significantly compared with Freund adjuvant, and antibody titer increased.Conclusion: Tetanus toxoid loaded TRIMETHYL CHITOSAN NANOPARTICLES increase the stimulation of immune system and are more effective in comparison with Freund's adjuvant.

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APA: Copy

GHALAVAND, MAJDEDIN, SAADATI, MOJTABA, SALIMIAN, JAFAR, ABBASI, EBRAHIM, & AHMADI, ALI. (2017). SYNTHESIS AND IMMUNOGENISITY EVALUATION OF TETANUS TOXOID ENCAPSULATED TRIMETHYL CHITOSAN NANOPARTICLES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(145), 54-62. SID. https://sid.ir/paper/45782/en

Vancouver: Copy

GHALAVAND MAJDEDIN, SAADATI MOJTABA, SALIMIAN JAFAR, ABBASI EBRAHIM, AHMADI ALI. SYNTHESIS AND IMMUNOGENISITY EVALUATION OF TETANUS TOXOID ENCAPSULATED TRIMETHYL CHITOSAN NANOPARTICLES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;26(145):54-62. Available from: https://sid.ir/paper/45782/en

IEEE: Copy

MAJDEDIN GHALAVAND, MOJTABA SAADATI, JAFAR SALIMIAN, EBRAHIM ABBASI, and ALI AHMADI, “SYNTHESIS AND IMMUNOGENISITY EVALUATION OF TETANUS TOXOID ENCAPSULATED TRIMETHYL CHITOSAN NANOPARTICLES,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 145, pp. 54–62, 2017, [Online]. Available: https://sid.ir/paper/45782/en

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