HISTOLOGIC AND HISTOMORPHOMETRIC EVALUATION OF OSTEOGENESIS INDUCED BY IMPLANTATION OF OCTACALCIUM PHOSPHATE-GELATIN COMPOSITE IN TIBIA BONE DEFECTS IN RAT

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SARGOLZAEI AVAL FEREYDOON; ETEGHADI ABDOLLSAMAD; ARAB MOHAMMAD REZA; SARGOLZAEI AVAL NARJES

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:27 | Issue:150 Page(s): 17-26

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Title

HISTOLOGIC AND HISTOMORPHOMETRIC EVALUATION OF OSTEOGENESIS INDUCED BY IMPLANTATION OF OCTACALCIUM PHOSPHATE-GELATIN COMPOSITE IN TIBIA BONE DEFECTS IN RAT

Author(s)

SARGOLZAEI AVAL FEREYDOON | ETEGHADI ABDOLLSAMAD | ARAB MOHAMMAD REZA | SARGOLZAEI AVAL NARJES | Issue Writer Certificate

Keywords

OCTACALCIUM PHOSPHATEQ2

GELATINQ2

OSTEOGENESIS INDUCEDQ1

BONE RECONSTRUCTIONQ3

Abstract

Background and purpose: Reconstruction of bone defects remains one of the most challenges encountered by orthopedic and reparative surgeons. The purpose of this study was to assess the osteogenic potential of OCTACALCIUM PHOSPHATE (OCP) and OCTACALCIUM PHOSPHATE/gelatin (OCP/G) composite in the tibia bone defects in rats.Materials and methods: This experimental study was conducted in 72 male Sprague Dawley rats. The rats were divided into experimental (OCP/G and OCP) and control groups (n=24 per group). Full thickness critical size trephine defects were made in the rat's tibial bones and filled with 6 mg of OCP and OCP/G composite in experimental groups. The control group had no intervention. On days 7, 14, 21 and, 56 after implantation, the rats were decapitated and bone samples were collected. Then, 5mm thick sections were cut and stained with H&E. Finally, the amount of newly formed bone was measured using Dunnett T3 test.Results: In experimental groups, the new bone formation was initiated at the defect margins in day 7 after implantation. During the remaining days, in addition to bone formation in deep parts of the defect, the newly formed bones were found to be more mature. In the control group, the newly formed bones were seen near to the defect margins. There were significant differences in the amount of newly formed bone between the experimental and control groups (P<0.001).Conclusion: This biomaterial could be used in the repair of long bone defects in clinical situations.

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APA: Copy

SARGOLZAEI AVAL, FEREYDOON, ETEGHADI, ABDOLLSAMAD, ARAB, MOHAMMAD REZA, & SARGOLZAEI AVAL, NARJES. (2017). HISTOLOGIC AND HISTOMORPHOMETRIC EVALUATION OF OSTEOGENESIS INDUCED BY IMPLANTATION OF OCTACALCIUM PHOSPHATE-GELATIN COMPOSITE IN TIBIA BONE DEFECTS IN RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(150), 17-26. SID. https://sid.ir/paper/45958/en

Vancouver: Copy

SARGOLZAEI AVAL FEREYDOON, ETEGHADI ABDOLLSAMAD, ARAB MOHAMMAD REZA, SARGOLZAEI AVAL NARJES. HISTOLOGIC AND HISTOMORPHOMETRIC EVALUATION OF OSTEOGENESIS INDUCED BY IMPLANTATION OF OCTACALCIUM PHOSPHATE-GELATIN COMPOSITE IN TIBIA BONE DEFECTS IN RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;27(150):17-26. Available from: https://sid.ir/paper/45958/en

IEEE: Copy

FEREYDOON SARGOLZAEI AVAL, ABDOLLSAMAD ETEGHADI, MOHAMMAD REZA ARAB, and NARJES SARGOLZAEI AVAL, “HISTOLOGIC AND HISTOMORPHOMETRIC EVALUATION OF OSTEOGENESIS INDUCED BY IMPLANTATION OF OCTACALCIUM PHOSPHATE-GELATIN COMPOSITE IN TIBIA BONE DEFECTS IN RAT,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 150, pp. 17–26, 2017, [Online]. Available: https://sid.ir/paper/45958/en

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