IMMUNOLOGICAL EVALUATION OF RECOMBINANT HIV1 VIRIONS WITH NOVEL ADJUVANTS IN BALB/C MICE MODEL

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SADAT SEYED MAHDI; ZABIHOLLAHI REZVAN; JAVADI FUZIEH; VAHABPOUR RUHOLAH; SIADAT SEYED DAVAR; AZADMANESH KEYHAN; MOSHIRI ARFA; PARIVAR KAZEM; AGHASADEGHI MOHAMAD REZA

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Journal: Journal of Mazandaran University of Medical Sciences Year:2011 | Volume:21 | Issue:84 Page(s): 13-21

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Title

IMMUNOLOGICAL EVALUATION OF RECOMBINANT HIV1 VIRIONS WITH NOVEL ADJUVANTS IN BALB/C MICE MODEL

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Keywords

HIV-1 RECOMBINANT VIRIONSQ2

IMMUNOLOGICAL ADJUVANTSQ2

IMMUNIZATIONQ2

Abstract

Background and purpose: Finding an efficient vaccine against HIV infection is still a major concern and a great challenge. In our previous study, HIV-1 virions with capability of a single replication were produced. In the present study their immunological evaluation has been carried out to study their induction of cellular and humoral responses in mice model.Materials and methods: In this study, first and second virion generations were produced in human HEK293T cells, and were injected to three different mice groups in three doses with or without adjuvants. After the last injection, immune responses were evaluated in serum and spleen cells of mice using ELISA.Results: Although all animals vaccinated with different immunogen regimens did develop cellular responses, in the main group injected with novel adjuvants, the highest levels of specific antibody, IFN-Y, IL-4 an also most IFN-Y excreting cells were evident, which is suggestive of a strong cellular response in these cells.Conclusion: An effective vaccine against HIV requires induction of strong humoral and cellular responses. Hence, these results demonstrate the high immune system stimulating capabilities of virion injection regime accompanied by M720 and CpG adjuvants, which provides the potential for an efficient HIV vaccine.

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APA: Copy

SADAT, SEYED MAHDI, ZABIHOLLAHI, REZVAN, JAVADI, FUZIEH, VAHABPOUR, RUHOLAH, SIADAT, SEYED DAVAR, AZADMANESH, KEYHAN, MOSHIRI, ARFA, PARIVAR, KAZEM, & AGHASADEGHI, MOHAMAD REZA. (2011). IMMUNOLOGICAL EVALUATION OF RECOMBINANT HIV1 VIRIONS WITH NOVEL ADJUVANTS IN BALB/C MICE MODEL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 21(84), 13-21. SID. https://sid.ir/paper/45976/en

Vancouver: Copy

SADAT SEYED MAHDI, ZABIHOLLAHI REZVAN, JAVADI FUZIEH, VAHABPOUR RUHOLAH, SIADAT SEYED DAVAR, AZADMANESH KEYHAN, MOSHIRI ARFA, PARIVAR KAZEM, AGHASADEGHI MOHAMAD REZA. IMMUNOLOGICAL EVALUATION OF RECOMBINANT HIV1 VIRIONS WITH NOVEL ADJUVANTS IN BALB/C MICE MODEL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;21(84):13-21. Available from: https://sid.ir/paper/45976/en

IEEE: Copy

SEYED MAHDI SADAT, REZVAN ZABIHOLLAHI, FUZIEH JAVADI, RUHOLAH VAHABPOUR, SEYED DAVAR SIADAT, KEYHAN AZADMANESH, ARFA MOSHIRI, KAZEM PARIVAR, and MOHAMAD REZA AGHASADEGHI, “IMMUNOLOGICAL EVALUATION OF RECOMBINANT HIV1 VIRIONS WITH NOVEL ADJUVANTS IN BALB/C MICE MODEL,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 84, pp. 13–21, 2011, [Online]. Available: https://sid.ir/paper/45976/en

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