EVALUATION OF CARBOMER, CMC AND HPMC ON DISSOLUTION AND BIOADHESION OF BUCCOADHESIVE CINNAMALDEHYDE TABLETS

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SAEEDI MAJID; AKBARI JAFAR; MORTEZA SEMNANI KATAYOON; ROSTAMKALAEI SEYYED SOHRAB; FATHALINEJAD FATEMEH; KHOSHVISHKAIE ELNAZ

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:27 | Issue:157 Page(s): 70-82

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Title

EVALUATION OF CARBOMER, CMC AND HPMC ON DISSOLUTION AND BIOADHESION OF BUCCOADHESIVE CINNAMALDEHYDE TABLETS

Author(s)

Keywords

CINNAMALDEHYDEQ1

MUCOADHESIVEQ2

POLYMERQ3

FORMULATIONQ3

TRANSMUCOSAL DRUG DELIVERYQ1

Abstract

Background and purpose: TRANSMUCOSAL DRUG DELIVERY unlike oral drug delivery has someadvantages including deletion of first past effect and prevention of drug removal in gastro-intestinal tractand enzymatic flora. This study aimed at evaluating the effect of CMC, cerbomer and HPMC onCINNAMALDEHYDE release from FORMULATION matrix and mucoadhesion of these FORMULATIONs. Materials and methods: In this experimental research, nine FORMULATIONs were selected andseveral tests including flowability, compressibility, hardness, assay, friability, swelling, and bioadhesiveforce were done. Results: According to the study, the angles of repose for all FORMULATIONs were between20. 06± 1. 67 and 31. 93± 2. 44. In addition, F5 and F6 had the most regular drug release patterns while F8and F9 were found to have the fastest drug release. Maximum bioadhesive strength was observed in F8and F9 but the minimum was observed in F3 and F4. Conclusion: Drug delivery studies are of great importance, particularly for the drugs that do nothave therapeutic efficacy in other routs of administration. According to current findings, HPMC inducesthe best FORMULATION for TRANSMUCOSAL DRUG DELIVERY.

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APA: Copy

SAEEDI, MAJID, AKBARI, JAFAR, MORTEZA SEMNANI, KATAYOON, ROSTAMKALAEI, SEYYED SOHRAB, FATHALINEJAD, FATEMEH, & KHOSHVISHKAIE, ELNAZ. (2018). EVALUATION OF CARBOMER, CMC AND HPMC ON DISSOLUTION AND BIOADHESION OF BUCCOADHESIVE CINNAMALDEHYDE TABLETS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(157 ), 70-82. SID. https://sid.ir/paper/46032/en

Vancouver: Copy

SAEEDI MAJID, AKBARI JAFAR, MORTEZA SEMNANI KATAYOON, ROSTAMKALAEI SEYYED SOHRAB, FATHALINEJAD FATEMEH, KHOSHVISHKAIE ELNAZ. EVALUATION OF CARBOMER, CMC AND HPMC ON DISSOLUTION AND BIOADHESION OF BUCCOADHESIVE CINNAMALDEHYDE TABLETS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(157 ):70-82. Available from: https://sid.ir/paper/46032/en

IEEE: Copy

MAJID SAEEDI, JAFAR AKBARI, KATAYOON MORTEZA SEMNANI, SEYYED SOHRAB ROSTAMKALAEI, FATEMEH FATHALINEJAD, and ELNAZ KHOSHVISHKAIE, “EVALUATION OF CARBOMER, CMC AND HPMC ON DISSOLUTION AND BIOADHESION OF BUCCOADHESIVE CINNAMALDEHYDE TABLETS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 157 , pp. 70–82, 2018, [Online]. Available: https://sid.ir/paper/46032/en

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