COMPARISON OF PREOPERATIVE ONDANSETRON AND DEXAMETHASONE IN PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER MIDDLE EAR SURGERIES

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EYDI MAHMOOD; HOSSAINZADEH HAMZEH; KOLAHDOUZAN KHOSRO; SEYED TOTONCHI SEYED JAVAD; MARJANI KARIM

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2011 | Volume:33 | Issue:3 Page(s): 52-57

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Title

COMPARISON OF PREOPERATIVE ONDANSETRON AND DEXAMETHASONE IN PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER MIDDLE EAR SURGERIES

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Keywords

POSTOPERATIVE NAUSEA AND VOMITINGQ3

ONDANSETRONQ2

DEXAMETHASONEQ3

MIDDLE EARQ3

COMPLICATIONQ3

Abstract

Background and Objectives: POSTOPERATIVE NAUSEA AND VOMITING (PONV) is frequent adverse event of anesthesia and surgery. Patients after MIDDLE EAR surgeries are in greater risk of PONV. Likewise, this COMPLICATION may destroy results of reconstruction and anatomical alignments. Numerous antiemetics have been studied for the prevention and treatment of PONV in patients scheduled for MIDDLE EAR surgeries. This study aimed at comparing intravenous ONDANSETRON and DEXAMETHASONE in this regard.Materials and Methods: In a double-blind randomized clinical trial, 219 candidates of MIDDLE EAR surgery were randomized in three groups; O, D and P and studied in Tabriz Imam Reza Hospital. Patients in group O received ONDANSETRON (4 mg, IV), in group D received DEXAMETHASONE (8 mg, IV), and in group P placebo prior to induction of anesthesia. Incidence of PONV, as well as its severity (according to Beilville scoring system) was documented during 24 hours after surgery and compared between the three groups.Results: During 2-8 and 8-16 hours after operation, the incidence of PONV was significantly higher in group P (P<0.001). Similar results were documented regarding the severity of PONV.Conclusion: Intravenous ONDANSETRON and DEXAMETHASONE are both more effective than placebo in controlling the PONV after MIDDLE EAR surgeries. DEXAMETHASONE is significantly more effective than ONDANSETRON in preventing the PONV.

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APA: Copy

EYDI, MAHMOOD, HOSSAINZADEH, HAMZEH, KOLAHDOUZAN, KHOSRO, SEYED TOTONCHI, SEYED JAVAD, & MARJANI, KARIM. (2011). COMPARISON OF PREOPERATIVE ONDANSETRON AND DEXAMETHASONE IN PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER MIDDLE EAR SURGERIES. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 33(3), 52-57. SID. https://sid.ir/paper/46737/en

Vancouver: Copy

EYDI MAHMOOD, HOSSAINZADEH HAMZEH, KOLAHDOUZAN KHOSRO, SEYED TOTONCHI SEYED JAVAD, MARJANI KARIM. COMPARISON OF PREOPERATIVE ONDANSETRON AND DEXAMETHASONE IN PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER MIDDLE EAR SURGERIES. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;33(3):52-57. Available from: https://sid.ir/paper/46737/en

IEEE: Copy

MAHMOOD EYDI, HAMZEH HOSSAINZADEH, KHOSRO KOLAHDOUZAN, SEYED JAVAD SEYED TOTONCHI, and KARIM MARJANI, “COMPARISON OF PREOPERATIVE ONDANSETRON AND DEXAMETHASONE IN PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER MIDDLE EAR SURGERIES,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 33, no. 3, pp. 52–57, 2011, [Online]. Available: https://sid.ir/paper/46737/en

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