ASSOCIATION OF PAI-1 SERUM LEVELS AND POLYMORPHISM OF GENE OF PLASMINOGENACTIVATOR INHIBITOR-1 IN PATIENT OF NON-DIABETIC AND NON-SMOKER WITH CORONARYARTERY DISEASE

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KHAKI KHATIBI FATEMEH; Karimian Ansar

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:40 | Issue:3 Page(s): 44-48

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Title

ASSOCIATION OF PAI-1 SERUM LEVELS AND POLYMORPHISM OF GENE OF PLASMINOGENACTIVATOR INHIBITOR-1 IN PATIENT OF NON-DIABETIC AND NON-SMOKER WITH CORONARYARTERY DISEASE

Author(s)

KHAKI KHATIBI FATEMEH | Karimian Ansar | Issue Writer Certificate

Keywords

PLASMINOGEN ACTIVATOR INHIBITOR-1Q1

POLYMORPHISM OF PAI-1 GENEQ1

CORONARY ARTERY DISEASEQ1

NONDIABETICQ1

NON-SMOKERQ1

Abstract

Background: CORONARY ARTERY DISEASE (CAD) caused by atherosclerosis, Studies have shown that there are anumber of factors which are closely related to the development and progression of CAD that include Cellularbinding molecules like PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1), multiple cardiac risk factors and hemostasis. Inthe present study we made an attempt to evaluate the association of PAI-1 4G/4G polymorphism and fibrinolysismarkers example PAI-1 with CAD. Methods: In this study, 140 individual, including 70 subjects as patient group and 70 subjects in the controlgroup were considered. Blood samples were obtained from all participants, genomic DNA was extracted and the4G/4G polymorphism of PAI-1 was amplified using specific primers. Polymorphism in the-675 position inpromoter of PAI-1 was detected by PCR-RFLP method. Serum levels of PAI-1 in the samples were measured byELISA. Results: Level of PAI-1 serum was significantly different between the two groups. PAI-1 genotype distributionin this case is the frequency of genotype 4G/4G in the patient group compared with the control group had higher. PAI-1 in patients who had genotype 4G, have a higher level compared to homozygous 5G (p-value=0. 01). Significant differences between serum level of PAI-1 and PAI-1 gene polymorphism with the risk of CAD wasobserved. Conclusion: The 4G/4G POLYMORPHISM OF PAI-1 GENE is a useful marker for fibrinolytic activity. Thispolymorphism due to increased in plasma level of PAI-1 which causes defects in fibrinolytic activity so increasingthe occurrence of cardiovascular diseases.

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APA: Copy

KHAKI KHATIBI, FATEMEH, & Karimian, Ansar. (2018). ASSOCIATION OF PAI-1 SERUM LEVELS AND POLYMORPHISM OF GENE OF PLASMINOGENACTIVATOR INHIBITOR-1 IN PATIENT OF NON-DIABETIC AND NON-SMOKER WITH CORONARYARTERY DISEASE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 40(3 ), 44-48. SID. https://sid.ir/paper/46771/en

Vancouver: Copy

KHAKI KHATIBI FATEMEH, Karimian Ansar. ASSOCIATION OF PAI-1 SERUM LEVELS AND POLYMORPHISM OF GENE OF PLASMINOGENACTIVATOR INHIBITOR-1 IN PATIENT OF NON-DIABETIC AND NON-SMOKER WITH CORONARYARTERY DISEASE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;40(3 ):44-48. Available from: https://sid.ir/paper/46771/en

IEEE: Copy

FATEMEH KHAKI KHATIBI, and Ansar Karimian, “ASSOCIATION OF PAI-1 SERUM LEVELS AND POLYMORPHISM OF GENE OF PLASMINOGENACTIVATOR INHIBITOR-1 IN PATIENT OF NON-DIABETIC AND NON-SMOKER WITH CORONARYARTERY DISEASE,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 40, no. 3 , pp. 44–48, 2018, [Online]. Available: https://sid.ir/paper/46771/en

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