EFFECT OF AMLODIPINE ON AORTIC TISSUE CONCENTRATION OF ENDOTHELIN IN MALE RABBITS RECEIVING ATHEROGENIC DIET

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MIRZAEI FARIBA; MOHAMMADI MOSTAFA; ASLANABADI N.; BABAEI HOSSEIN; BONYADI M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:29 | Issue:4 Page(s): 73-77

Download Full-Text

Persian Verion

View:

970

Download:

Cites:

Information Journal Paper

Title

EFFECT OF AMLODIPINE ON AORTIC TISSUE CONCENTRATION OF ENDOTHELIN IN MALE RABBITS RECEIVING ATHEROGENIC DIET

Author(s)

Keywords

ATHEROSCLEROSISQ2

AMLODIPINE. ENDOTHELIN-1Q3

ATHEROSCLEROTIC RABBITQ3

Abstract

Background and Objectives: Different factors are involved in inducing and progressing of ATHEROSCLEROSIS. One of these factors is endothelin-1. Since in atherosclerotic vessels obvious and certain changes with abnormality in transferring of calcium ions are seen, some researchers suggested that calcium channel blockers can slow down the process of ATHEROSCLEROSIS.Materials and Methods: Thirty six male Newsland white rabbits were divided into four groups: The normal control group, normal group receiving amlodipine, high-cholesterol diet group and high-cholesterol diet with amlodipine group. After 8 weeks all animals anesthetized and blood and tissues samples were colleted.Results: The levels of cholesterol and triglyceride in groups of high-cholesterol diet and high-cholesterol diet plus amlodipine in comparison to control group increased significantly (p=0.000). In plasma endothelin-1 level results indicate that difference among groups of amlodipine, high-cholesterol diet and high-cholesterol diet plus amlodipine with control group is significant (p=0.000). The tissue levels of endothelin in aorta artery difference among groups of high-cholesterol diet and high-cholesterol diet plus amlodipine with control is significant (p=0.000) but difference between amlodipine and control groups is not significant and difference between high-cholesterol diet and high-cholesterol diet plus amlodipine groups is significant (p=0.000).Conclusion: High-cholesterol cause increase of plasma and tissue endothelin and amlodipine decrease levels of cholesterol and triglyceride and also in high lipid situation has effect on endothlin level and decrease of it in plasma and tissue.

Cites

No record.

References

No record.

Cite

APA: Copy

MIRZAEI, FARIBA, MOHAMMADI, MOSTAFA, ASLANABADI, N., BABAEI, HOSSEIN, & BONYADI, M.R.. (2008). EFFECT OF AMLODIPINE ON AORTIC TISSUE CONCENTRATION OF ENDOTHELIN IN MALE RABBITS RECEIVING ATHEROGENIC DIET. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 29(4), 73-77. SID. https://sid.ir/paper/46969/en

Vancouver: Copy

MIRZAEI FARIBA, MOHAMMADI MOSTAFA, ASLANABADI N., BABAEI HOSSEIN, BONYADI M.R.. EFFECT OF AMLODIPINE ON AORTIC TISSUE CONCENTRATION OF ENDOTHELIN IN MALE RABBITS RECEIVING ATHEROGENIC DIET. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;29(4):73-77. Available from: https://sid.ir/paper/46969/en

IEEE: Copy

FARIBA MIRZAEI, MOSTAFA MOHAMMADI, N. ASLANABADI, HOSSEIN BABAEI, and M.R. BONYADI, “EFFECT OF AMLODIPINE ON AORTIC TISSUE CONCENTRATION OF ENDOTHELIN IN MALE RABBITS RECEIVING ATHEROGENIC DIET,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 4, pp. 73–77, 2008, [Online]. Available: https://sid.ir/paper/46969/en

Related Journal Papers