EFFECT OF THREE MONTHS EXERCISE ON EXPRESSION OF ENDITHELIN-1 MRNA IN THE LUNG TISSUE

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AHMADIASL N.; NIKNAZAR SOMAYEH; FARAJNIA SAFAR; ALIPOUR M.R.

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Title

EFFECT OF THREE MONTHS EXERCISE ON EXPRESSION OF ENDITHELIN-1 MRNA IN THE LUNG TISSUE

Author(s)

AHMADIASL N. | NIKNAZAR SOMAYEH | FARAJNIA SAFAR | ALIPOUR M.R. | Issue Writer Certificate

Keywords

ENDOTHELIN-1Q2

EXERCISEQ1

LUNGQ1

Abstract

Objectives: ENDOTHELIN-1 (ET-1) is a potent vasoconstrictor peptide produced by vascular endothelial cells. In the LUNG, the highest levels of ET-1was secreted by endothelium, smooth muscle airway epithelium and a variety of other cells. EXERCISE is an important factor that affects ET-1 expression and production. This substance plays an important role in LUNG disease. In the present study the effects of three months EXERCISE in the expression of ET-1 gene in LUNGs tissue of male rats were investigated.Method: 20 male Wistar rats (235 ± 27) were selected. The rats were randomly divided into two groups (n=10). EXERCISE rats ran on a treadmill for 60 min at a speed of 25 m/min daily for 3 months. 48 h after the last EXERCISE the LUNGs were removed and were stored in -70oC. Total RNA was extracted from the LUNG tissue and the expression of ET- 1 mRNA was assessed by RT-PCR.Results: the expression of ET-1 mRNA in the LUNG was significantly higher in the EXERCISE rats than in the control rats (P<0.05).Conclusion: The results of this study showed that three months EXERCISE increased the ET-1 expression in the LUNG and this effect could increase the blood flow of LUNG.

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APA: Copy

AHMADIASL, N., NIKNAZAR, SOMAYEH, FARAJNIA, SAFAR, & ALIPOUR, M.R.. (2008). EFFECT OF THREE MONTHS EXERCISE ON EXPRESSION OF ENDITHELIN-1 MRNA IN THE LUNG TISSUE. PHARMACEUTICAL SCIENCES, -(3), 59-62. SID. https://sid.ir/paper/48615/en

Vancouver: Copy

AHMADIASL N., NIKNAZAR SOMAYEH, FARAJNIA SAFAR, ALIPOUR M.R.. EFFECT OF THREE MONTHS EXERCISE ON EXPRESSION OF ENDITHELIN-1 MRNA IN THE LUNG TISSUE. PHARMACEUTICAL SCIENCES[Internet]. 2008;-(3):59-62. Available from: https://sid.ir/paper/48615/en

IEEE: Copy

N. AHMADIASL, SOMAYEH NIKNAZAR, SAFAR FARAJNIA, and M.R. ALIPOUR, “EFFECT OF THREE MONTHS EXERCISE ON EXPRESSION OF ENDITHELIN-1 MRNA IN THE LUNG TISSUE,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 59–62, 2008, [Online]. Available: https://sid.ir/paper/48615/en

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