RENIN - ANGIOTENSIN SYSTEM POLYMORPHISMS AND RENAL GRAFT FUNCTION IN RENAL TRANSPLANT RECIPIENTS IN TABRIZ EMAM KHOMEINI HOSPITAL

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NOUROUZIAN AVAL M.; ARGANI H.; AGHAEI SHAHSAVARI M.; VEYSI P.; JABARPOUR BONYADI MORTEZA; HAMZEHEI H.; ASGHARZADEH M.

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2007 | Volume:29 | Issue:3 Page(s): 115-120

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Title

RENIN - ANGIOTENSIN SYSTEM POLYMORPHISMS AND RENAL GRAFT FUNCTION IN RENAL TRANSPLANT RECIPIENTS IN TABRIZ EMAM KHOMEINI HOSPITAL

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Keywords

POLYMORPHISMQ2

ANGIOTENSIN CONVERTING ENZYMEQ2

ANGIOTENSINOGENQ3

ANGIOTENSIN II TYPE 1 RECEPTORQ3

RENAL GRAFT FUNCTIONQ3

Abstract

Background and Objectives: Relation between renin-angiotensin system gene POLYMORPHISM and renal allograft dysfunction is the matter of debate. We designed this study to evaluate this controversy in Iranian patients.Materials and Methods: The present study was performed on 108 renal transplant recipients.Following of the DNA extraction, the genotypes of the ANGIOTENSIN CONVERTING ENZYME (I/D), ANGIOTENSINOGEN (M235T) and ANGIOTENSIN II TYPE 1 RECEPTOR (A1166C) were determined by PCR. The magnitude of clearance of creatinine in the setting of each of the above reninangiotensin system POLYMORPHISMs was determined by MDRD formula. P£0.05 was considered to indicate statistical significance.Results: There was no association between the each genotype of the renin-angiotensin system and clearance of creatinine, serum urea, cyclosporine through level and the degree of urinary protein excretion rate, But in addition of the genotypes, the patients with DD+CC genotype in comparison of the patients with II+AA genotype had lower clearance of creatinine and higher creatinine level, urinary protein excretion rate (P=0.05, P=0.002, and P=0.03, respectively). Likewise, other combinations hadn’t such association.Conclusion: Although, none of the gene POLYMORPHISMs of the renin-angiotensin system had any impact on renal allograft function, but evaluation of combinations of these genotypes can predict the outcome of renal allograft function.

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APA: Copy

NOUROUZIAN AVAL, M., ARGANI, H., AGHAEI SHAHSAVARI, M., VEYSI, P., JABARPOUR BONYADI, MORTEZA, HAMZEHEI, H., & ASGHARZADEH, M.. (2007). RENIN - ANGIOTENSIN SYSTEM POLYMORPHISMS AND RENAL GRAFT FUNCTION IN RENAL TRANSPLANT RECIPIENTS IN TABRIZ EMAM KHOMEINI HOSPITAL. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 29(3), 115-120. SID. https://sid.ir/paper/47181/en

Vancouver: Copy

NOUROUZIAN AVAL M., ARGANI H., AGHAEI SHAHSAVARI M., VEYSI P., JABARPOUR BONYADI MORTEZA, HAMZEHEI H., ASGHARZADEH M.. RENIN - ANGIOTENSIN SYSTEM POLYMORPHISMS AND RENAL GRAFT FUNCTION IN RENAL TRANSPLANT RECIPIENTS IN TABRIZ EMAM KHOMEINI HOSPITAL. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;29(3):115-120. Available from: https://sid.ir/paper/47181/en

IEEE: Copy

M. NOUROUZIAN AVAL, H. ARGANI, M. AGHAEI SHAHSAVARI, P. VEYSI, MORTEZA JABARPOUR BONYADI, H. HAMZEHEI, and M. ASGHARZADEH, “RENIN - ANGIOTENSIN SYSTEM POLYMORPHISMS AND RENAL GRAFT FUNCTION IN RENAL TRANSPLANT RECIPIENTS IN TABRIZ EMAM KHOMEINI HOSPITAL,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 3, pp. 115–120, 2007, [Online]. Available: https://sid.ir/paper/47181/en

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