THE STUDY OF THE RELATIONSHIP BETWEEN RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS AND PANEL-REACTIVE ANTIBODIES IN RENAL TRANSPLANT CANDIDATES

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NOUROUZIAN AVAL M.; VEYSI P.; AGHAEI SHAHSAVARI M.; ARGANI H.; RASHTCHIZADEH N.; GHORBANI HAGHJOU A.

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Journal: Journal of Ardabil University of Medical Sciences Year:2007 | Volume:7 | Issue:3 (25) Page(s): 296-301

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Title

THE STUDY OF THE RELATIONSHIP BETWEEN RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS AND PANEL-REACTIVE ANTIBODIES IN RENAL TRANSPLANT CANDIDATES

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Keywords

PRAQ3

RAS POLYMORPHISMQ3

PCRQ2

RENAL TRANSPLANTQ3

Abstract

Background & Objectives: Panel-reactive antibody (PRA) is a routine test to evaluate for sensitized human leukocyte antigens (HLA) before kidney transplantation. The present study evaluates the correlation of renin-angiotensin system (RAS) polymorphisms with the level of PRA in RENAL TRANSPLANT candidates.Methods: This study included 108 RENAL TRANSPLANT candidates. The current patients sera were screened by standard complement-dependent microlymphocytotoxicity technique. RAS POLYMORPHISMs were determined by polymerase chain reaction. PRA<10, 10-29, 30-49, and ³50 considered as negative, mild, moderate, and highly positive PRA, respectively.Results: Twelve (11.1%) patients had positive PRA, among them 10 (83.3%) had mild and 2 (16.7%) of them had moderate PRA levels; we had no highly positive PRA. Ninety-six of cases (88.9%) were negative for PRA. There was no significant correlation between discrete RAS POLYMORPHISMs (alone or together) and the degree of panel antibody reactivity (P>0.05). Conclusion: We suggest that none of the RAS POLYMORPHISMs could predict the positivity degree of PRA level.

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APA: Copy

NOUROUZIAN AVAL, M., VEYSI, P., AGHAEI SHAHSAVARI, M., ARGANI, H., RASHTCHIZADEH, N., & GHORBANI HAGHJOU, A.. (2007). THE STUDY OF THE RELATIONSHIP BETWEEN RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS AND PANEL-REACTIVE ANTIBODIES IN RENAL TRANSPLANT CANDIDATES. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 7(3 (25)), 296-301. SID. https://sid.ir/paper/59685/en

Vancouver: Copy

NOUROUZIAN AVAL M., VEYSI P., AGHAEI SHAHSAVARI M., ARGANI H., RASHTCHIZADEH N., GHORBANI HAGHJOU A.. THE STUDY OF THE RELATIONSHIP BETWEEN RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS AND PANEL-REACTIVE ANTIBODIES IN RENAL TRANSPLANT CANDIDATES. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2007;7(3 (25)):296-301. Available from: https://sid.ir/paper/59685/en

IEEE: Copy

M. NOUROUZIAN AVAL, P. VEYSI, M. AGHAEI SHAHSAVARI, H. ARGANI, N. RASHTCHIZADEH, and A. GHORBANI HAGHJOU, “THE STUDY OF THE RELATIONSHIP BETWEEN RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS AND PANEL-REACTIVE ANTIBODIES IN RENAL TRANSPLANT CANDIDATES,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 7, no. 3 (25), pp. 296–301, 2007, [Online]. Available: https://sid.ir/paper/59685/en

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