RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS AND HB LEVEL IN RENAL ALLOGRAFTS: A COMPARATIVE STUDY BETWEEN LOSARTAN AND ENALAPRIL

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AGHAEI SHAHSAVARI M.; NOUROUZIAN AVAL M.; VEYSI P.; ARGANI H.; GHORBANI HAGHJOU A.; RASHTCHIZADEH N.

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Journal: Studies in Medical Sciences Year:2007 | Volume:18 | Issue:3 Page(s): 582-588

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Title

RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS AND HB LEVEL IN RENAL ALLOGRAFTS: A COMPARATIVE STUDY BETWEEN LOSARTAN AND ENALAPRIL

Author(s)

Keywords

RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMSQ3

LOSARTANQ3

ENALAPRILQ3

RENAL TRANSPLANTQ3

HBQ3

Abstract

Background & Aims: Hemoglobin (Hb) concentration may or may not be decreased by blockade of renin-angiotensin system (RAS) after RENAL TRANSPLANTation. In this study, HB concentration secondary to ENALAPRIL (E) and /or LOSARTAN (L) is evaluated with respect to RAS polymorphisms.Materials & Methods: After determination of RAS polymorphisms consist of ACE (DD, non-DD), angiotensinogen (TT, non-TT) and angiotensin receptor (CC, non-CC) by polymerase chain reaction, seventy RENAL TRANSPLANT recipients were recruited to four groups randomly; first and second groups were treated with E (10mg/d, 15 patients) and L (50mg/d, 20 patients) alone, respectively. The third group received E+L (10mg/d + 50 mg/d, 13 patients) and the forth group (22 patients) received no medication. The treatment protocol was followed for 16 weeks. Complete blood counts were checked before treatment and every 2 months. Values were expressed as mean±SD; P<0.05 was considered to indicate statistical significance.Results: Treatment for 4 months decreased the HB level in the E+L (14.15±0.94 to 12.06±0.66 g/dl, P=0.000); E (14.00±0.86 to 13.11±0.82 g/dl, P=0.02) and L (14.12±0.90 to 12.10±3.25 g/dl, P=0.01) groups, but not in the control group (13.55±0.70 to 13.36±0.69 g/dl, P=0.22). None of the above regimens was more HB reducer than the others (P=0.21). DD genotype of ACE was the only genotype among the RAS polymorphisms, which associated with higher HB concentration. (14.29±0.41 vs. 13.44±0.76, P=0.04) but none of the RAS polymorphisms could predict the intensity of the reduced HB according to the type of treatment. Any other sets for RAS (alone or together) did not impact on HB levels in pre and post intervention.Conclusion: Our findings suggest that low dosage of E and/or L in RTRs can decrease HB levels regardless of the RAS polymorphisms. DD genotype of ACE polymorphism was associated with higher HB concentration.

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APA: Copy

AGHAEI SHAHSAVARI, M., NOUROUZIAN AVAL, M., VEYSI, P., ARGANI, H., GHORBANI HAGHJOU, A., & RASHTCHIZADEH, N.. (2007). RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS AND HB LEVEL IN RENAL ALLOGRAFTS: A COMPARATIVE STUDY BETWEEN LOSARTAN AND ENALAPRIL. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 18(3), 582-588. SID. https://sid.ir/paper/64117/en

Vancouver: Copy

AGHAEI SHAHSAVARI M., NOUROUZIAN AVAL M., VEYSI P., ARGANI H., GHORBANI HAGHJOU A., RASHTCHIZADEH N.. RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS AND HB LEVEL IN RENAL ALLOGRAFTS: A COMPARATIVE STUDY BETWEEN LOSARTAN AND ENALAPRIL. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2007;18(3):582-588. Available from: https://sid.ir/paper/64117/en

IEEE: Copy

M. AGHAEI SHAHSAVARI, M. NOUROUZIAN AVAL, P. VEYSI, H. ARGANI, A. GHORBANI HAGHJOU, and N. RASHTCHIZADEH, “RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS AND HB LEVEL IN RENAL ALLOGRAFTS: A COMPARATIVE STUDY BETWEEN LOSARTAN AND ENALAPRIL,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 18, no. 3, pp. 582–588, 2007, [Online]. Available: https://sid.ir/paper/64117/en

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