DETERMINING OF METHAMPHETAMIN EFFECTS ON SPERM PARAMETERS OF MATURE RAT

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TAGHAVI M.M.; ALAVI S.H.; MOALEM SEYED ADEL; VARASTEH A.A.R.

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Journal: Journal of Kerman University of Medical Sciences Year:2008 | Volume:15 | Issue:1 Page(s): 61-69

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Title

DETERMINING OF METHAMPHETAMIN EFFECTS ON SPERM PARAMETERS OF MATURE RAT

Author(s)

TAGHAVI M.M. | ALAVI S.H. | MOALEM SEYED ADEL | VARASTEH A.A.R. | Issue Writer Certificate

Keywords

METHAMPHETAMINEQ1

SPERM PARAMETERSQ3

EPIDIDYMISQ3

RATQ2

Abstract

Introduction: METHAMPHETAMINE (MAMP) is a central nervous system stimulant, but it is increasingly abused as a psychedelic tablet by teenagers and young adults. In this experimental study, we evaluate the effects of MAMP on SPERM PARAMETERS of mature RAT.Methods: MAMP or saline were injected in three experiments as follow: In the first experiment, twenty-four RATs were injected one time with 10mg/kg MAMP, and sperms were sampled from tail of EPIDIDYMIS 6, 12, 24, 48, 72, and 168 h after injection (n=4, at each time). Six RATs injected with saline served as controls. In the second experiment, four groups of RATs each consisting of four RATs were administered MAMP (5, 10 and 15mg/kg) or saline, respectively, and examined 24h later. In the third experiment, 16 RATs were evenly divided into four groups (1, 5, and 10 mg/kg MAMP and control) and were injected MAMP or saline once daily for 14 consecutive days (spermatogenesis period) and sperms were sampled 24 h after the last injection.The motility, concentration and morphology of the sampled sperms were evaluated. We also measured the body and testis weights and used the testis/body weight RATio as an index at the end of each experiment.Results: At 24 and 48 h after injection with a single dose of 10 mg/kg MAMP, the number of sperms decreased significantly in comparison with controls (p£0.001 and P£0.05 respectively). In the second experiment, the number of sperms for three doses of MAMP significantly decreased in the two upper doses (P<0.001) and in the lower dose (P£0.05).The results of the third experiment were similar but the decrease of sperms number was more than that in the second experiment. MAMP did not change the testis/body weight RATio in the first and second experiments, but it significantly decreased this index in RATs of the third experiment which received 10 and 5 mg/kg MAMP daily. We did not observe differences between experimental and control groups in motility and morphology of sperms.Conclusion: Our results indicate that the repeated administration and/or higher doses of MAMP reduce the number of mature sperms in the tail of EPIDIDYMIS and have adverse effects on the reproduction and fertility of MAMP users.

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APA: Copy

TAGHAVI, M.M., ALAVI, S.H., MOALEM, SEYED ADEL, & VARASTEH, A.A.R.. (2008). DETERMINING OF METHAMPHETAMIN EFFECTS ON SPERM PARAMETERS OF MATURE RAT. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 15(1), 61-69. SID. https://sid.ir/paper/479/en

Vancouver: Copy

TAGHAVI M.M., ALAVI S.H., MOALEM SEYED ADEL, VARASTEH A.A.R.. DETERMINING OF METHAMPHETAMIN EFFECTS ON SPERM PARAMETERS OF MATURE RAT. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;15(1):61-69. Available from: https://sid.ir/paper/479/en

IEEE: Copy

M.M. TAGHAVI, S.H. ALAVI, SEYED ADEL MOALEM, and A.A.R. VARASTEH, “DETERMINING OF METHAMPHETAMIN EFFECTS ON SPERM PARAMETERS OF MATURE RAT,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 1, pp. 61–69, 2008, [Online]. Available: https://sid.ir/paper/479/en

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