ENALAPRIL AND LOSARTAN AFFECT LIPID PEROXIDATION IN RENAL TRANSPLANT RECIPIENTS WITH RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS

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AGHAEI SHAHSAVARI M.; RASHTCHIZADEH N.; VEYSI P.; NOUROUZIAN AVAL M.; ARGANI H.; GHORBANI HAGHJOU A.; BABAEI HOSSEIN

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Journal: PHARMACEUTICAL SCIENCES Year:2006 | Volume:- | Issue:2 Page(s): 33-40

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Title

ENALAPRIL AND LOSARTAN AFFECT LIPID PEROXIDATION IN RENAL TRANSPLANT RECIPIENTS WITH RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS

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Keywords

ENALAPRILQ2

LOSARTANQ2

RAS POLYMORPHISMSQ2

MDAQ2

LPOQ2

Abstract

Objectives: In this study, the effect of ENALAPRIL (E) and/or LOSARTAN (L) on lipid peroxidation (LPO) is studied in renal transplant recipients (RTRs) with regarding to polymorphisms of renin-angiotensin system (RAS). Methods: fter determination of genotypes of the angiotensin converting enzyme (ACE I/D), angiotensinogen (AGT M235T) and angiogenesis II type 1 receptor (ATR1 A1166C) by polymerase chain reaction, sixty-four RTRs recruited to four groups randomly: first (13 patients) and second (20 patients) groups were treated with ENALAPRIL (E+: 10mg/d) and LOSARTAN (L+: 50 mg/d) alone, respectively. The third group (13 patients as positive control) received ENALAPRIL + LOSARTAN (E+L+: 10mg/d + 50 mg/d) and the forth group (18 patients as negative control) received no medication (E-L-). Malondialdehyde (MDA) as LPO marker was measured after 8 weeks. After 2 weeks as washout period, E group changed to L and vice versa as a cross-over design. They were followed for another 8 weeks and MDA was retested. Results: MDA level significantly decreased in all of the groups except the E-L-. Regardless of the treatment protocol, HDL-c, LDL-c, TG, total cholesterol and reduced MDA levels did not change (P>0.05). Although, patients with DD genotype of ACE had higher MDA (P=0.01) and TG (P=0.03) levels, RAS POLYMORPHISMS couldn’t predict the antioxidative response rate to the drugs (P>0.05). Conclusion: Although LPO is higher in DD genotype of ACE polymorphism; E and/or L reduce MDA regardless of the RAS genotypes.

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APA: Copy

AGHAEI SHAHSAVARI, M., RASHTCHIZADEH, N., VEYSI, P., NOUROUZIAN AVAL, M., ARGANI, H., GHORBANI HAGHJOU, A., & BABAEI, HOSSEIN. (2006). ENALAPRIL AND LOSARTAN AFFECT LIPID PEROXIDATION IN RENAL TRANSPLANT RECIPIENTS WITH RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS. PHARMACEUTICAL SCIENCES, -(2), 33-40. SID. https://sid.ir/paper/48452/en

Vancouver: Copy

AGHAEI SHAHSAVARI M., RASHTCHIZADEH N., VEYSI P., NOUROUZIAN AVAL M., ARGANI H., GHORBANI HAGHJOU A., BABAEI HOSSEIN. ENALAPRIL AND LOSARTAN AFFECT LIPID PEROXIDATION IN RENAL TRANSPLANT RECIPIENTS WITH RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS. PHARMACEUTICAL SCIENCES[Internet]. 2006;-(2):33-40. Available from: https://sid.ir/paper/48452/en

IEEE: Copy

M. AGHAEI SHAHSAVARI, N. RASHTCHIZADEH, P. VEYSI, M. NOUROUZIAN AVAL, H. ARGANI, A. GHORBANI HAGHJOU, and HOSSEIN BABAEI, “ENALAPRIL AND LOSARTAN AFFECT LIPID PEROXIDATION IN RENAL TRANSPLANT RECIPIENTS WITH RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 33–40, 2006, [Online]. Available: https://sid.ir/paper/48452/en

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