EFFECT OF DIFFERENT CONCENTRATIONS OF METHYLCELLULOSE ON CHEMICAL STABILITY OF AMPICILLIN SUSPENSIONS

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BARZEGAR JALALI M.; HANAEI J.; GHAFOURIAN T.

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Journal: PHARMACEUTICAL SCIENCES Year:2001 | Volume:- | Issue:1 Page(s): 9-14

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Title

EFFECT OF DIFFERENT CONCENTRATIONS OF METHYLCELLULOSE ON CHEMICAL STABILITY OF AMPICILLIN SUSPENSIONS

Author(s)

BARZEGAR JALALI M. | HANAEI J. | GHAFOURIAN T. | Issue Writer Certificate

Keywords

AMPICILLINQ3

SUSPENSIONQ3

METHYLCELLULOSEQ2

CHEMICAL STABILITYQ3

Abstract

Methylcellulose, MC, initially increased slightly CHEMICAL STABILITY of AMPICILLIN, AM, in aqueous SUSPENSIONs prepared nom pure drug powder and commercial drug powder for oral SUSPENSION which contained sucrose as well as other formulation ingredients when compared with the corresponding simple aqueous SUSPENSIONs (without MC). After termination of this initial period the length of which was longer for the pure powder than the commercial powder, the drug stability was not affected significantly in pure powder SUSPENSIONs by MC. However, MC increased considerably the rate of drug degradation in SUSPENSIONs prepared from the commercial powder following the initial period. Degradation rate of AM in these SUSPENSIONs which contained large amount of sucrose as sweetening agent depended on MC concentration. The higher the concentration the higher was the rate of AM decomposition. Because of the complexity of the situation, the stability data did not obey the zero order kinetics which is usually employed for linearization of the SUSPENSIONs stability data. In an attempt to clarify the effect of MC on degration of AM, the apparent solubility of AM was measured in presence of MC. The result showed that MC increased aqueous solubility of AM indicating a soluble complex formation between AM and MC. The complication was also confirmed by a subtraction spectrophotometric method. Since, the degradation of drugs in SUSPENSIONs usually occurs in the solution phase and according to previous findings sucrose catalysed the decomposition of AM, therefore, the increase in solubility of AM by MC in SUSPENSIONs of the commercial powder might increase sucrose catalysed degradation of this antibiotic. MC could also enhance the viscosity of the SUSPENSIONs and could decrease the decomposition rate of the drug through the reduction in collision rates of reacting molecules as it was evident in the initial periods. But, in AM SUSPENSIONs prepared of the commercial powder which contained sucrose, during the post initial period the degrading effect of MC seemed to overweigh its stabilizing effect.

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APA: Copy

BARZEGAR JALALI, M., HANAEI, J., & GHAFOURIAN, T.. (2001). EFFECT OF DIFFERENT CONCENTRATIONS OF METHYLCELLULOSE ON CHEMICAL STABILITY OF AMPICILLIN SUSPENSIONS. PHARMACEUTICAL SCIENCES, -(1), 9-14. SID. https://sid.ir/paper/48470/en

Vancouver: Copy

BARZEGAR JALALI M., HANAEI J., GHAFOURIAN T.. EFFECT OF DIFFERENT CONCENTRATIONS OF METHYLCELLULOSE ON CHEMICAL STABILITY OF AMPICILLIN SUSPENSIONS. PHARMACEUTICAL SCIENCES[Internet]. 2001;-(1):9-14. Available from: https://sid.ir/paper/48470/en

IEEE: Copy

M. BARZEGAR JALALI, J. HANAEI, and T. GHAFOURIAN, “EFFECT OF DIFFERENT CONCENTRATIONS OF METHYLCELLULOSE ON CHEMICAL STABILITY OF AMPICILLIN SUSPENSIONS,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 9–14, 2001, [Online]. Available: https://sid.ir/paper/48470/en

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