FORMULATION OF NIFEDIPINE OSMOTIC PUMP AND EVALUATION OF DRUG RELEASE FROM PREPARED FORMULATIONS

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SHOKRI J.; HANAEI J.; ADIBKIA KH.; ZARINTAN M.H.; MEHRPOUYA M.

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Journal: PHARMACEUTICAL SCIENCES Year:2004 | Volume:- | Issue:2 Page(s): 75-86

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Title

FORMULATION OF NIFEDIPINE OSMOTIC PUMP AND EVALUATION OF DRUG RELEASE FROM PREPARED FORMULATIONS

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Keywords

OSMOTIC PUMPQ2

NIFEDIPINEQ2

FORMULATIONQ3

DRUG RELEASEQ2

Abstract

In this study, we tried to formulate NIFEDIPINE once a day FORMULATION by using of OSMOTIC PUMP system. Several FORMULATIONs was prepared and DRUG RELEASE from each of them was measured by dissolution tester apparatus (No. II) in 3TC and 100rpm. NIFEDIPINE was protected from light during all of the steps. The various polymers with different viscosities and different molecular weights were used in the core FORMULATION such as HPMCE50LV, HPMCK100M, HPMCE5LV, PVPK30MN, NaCMC (200 and 1500 cps) and Carbapols (934 and 940). Among these polymers, HPMCE50LV was chosen as selected gelling agent for the system. KCI also selected as osmotic agent of system. The use of SLS in the core FORMULATION markedly increased the release of the drug from OSMOTIC PUMP. The DRUG RELEASE enhancement by SLS probably arises from the ability of SLS to suspending the drug particles in the FORMULATION and increasing of solubility. SLS also can increase wetting of drug particles and prevent them from agglomeration after penetrating of water into the system. Cellulose acetate was used in the FORMULATION of semi permeable membrane. Caster oil was used as plasticizers of semi permeable membrane in 1%w/w concentration. The effect of hole diameter on the release of FORMULATIONs also investigated. These studies showed that the hole diameter is very effective on the release of the drug from OSMOTIC PUMP and hence, the hole size of system should be optimized.

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APA: Copy

SHOKRI, J., HANAEI, J., ADIBKIA, KH., ZARINTAN, M.H., & MEHRPOUYA, M.. (2004). FORMULATION OF NIFEDIPINE OSMOTIC PUMP AND EVALUATION OF DRUG RELEASE FROM PREPARED FORMULATIONS. PHARMACEUTICAL SCIENCES, -(2), 75-86. SID. https://sid.ir/paper/48479/en

Vancouver: Copy

SHOKRI J., HANAEI J., ADIBKIA KH., ZARINTAN M.H., MEHRPOUYA M.. FORMULATION OF NIFEDIPINE OSMOTIC PUMP AND EVALUATION OF DRUG RELEASE FROM PREPARED FORMULATIONS. PHARMACEUTICAL SCIENCES[Internet]. 2004;-(2):75-86. Available from: https://sid.ir/paper/48479/en

IEEE: Copy

J. SHOKRI, J. HANAEI, KH. ADIBKIA, M.H. ZARINTAN, and M. MEHRPOUYA, “FORMULATION OF NIFEDIPINE OSMOTIC PUMP AND EVALUATION OF DRUG RELEASE FROM PREPARED FORMULATIONS,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 75–86, 2004, [Online]. Available: https://sid.ir/paper/48479/en

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