STUDY OF MITOMYCIN C APPLICATION IN TRABECULECTOMY OF HIGH RISK PATIENTS

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FERESHTEHKHOU M.A.; NOURINIA R.; ZARGHAMI N.A.

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Journal: PHARMACEUTICAL SCIENCES Year:2006 | Volume:- | Issue:1 Page(s): 41-46

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Title

STUDY OF MITOMYCIN C APPLICATION IN TRABECULECTOMY OF HIGH RISK PATIENTS

Author(s)

FERESHTEHKHOU M.A. | NOURINIA R. | ZARGHAMI N.A. | Issue Writer Certificate

Keywords

TRABECULECTOMYQ2

MITOMYCIN CQ2

GLAUCOMAQ2

Abstract

Objectives: Failure of Glaucoma filtering Bleb is caused mainly by proliferation of subconjunctival Fibroblasts and by their biosynthesis of collagen and other extra cellular Tissues. A number of antimetabolite drugs have been shown to suppress fibroblast activity. Mitomycin C is an antineoplastic antibiotic which is obtained from streptomyces caespitosis and inhibits DNA synthesis. Histological studies have shown that mitomycin stopped fibroblastic growth and proliferation. Therefore, the reason for using mitomycin C is increasing of surgical success and consistency of bleb and fistul in trabeculectomy. Since there is not an established dose of mitomycin C application (used dose is 0.1 – 0.4 mg), the aim of the present study is investigating mitomycin C in higher doses and longer application in high risk patients. Methods: This study was an experimental work in 2000-2002, during the study the patients who had glaucoma. IOP, more than 20 mmHg, optic nerve damaged and visual Acuity Reduced was entered the study. Among them, the patients, whom their disease was advancing in spite of using several antiglaucoma drugs, their disease was advancing, were selected for surgery. Thus the patients for Trabeculectomy in addition to having indication for surgery had one or more high risk factors. Results: After surgery, intraocular pressure decreased to 66%, success rate was 100% a thin avascular bleb was 90%, wound leak was 25%, shallow anterior chamber was 20%, choroidal detachment was 20%, and cataract development was 10% of all subjects. Conclusion: we concluded that the application of high dose of mitomycin C for longer period in high risk patients will be useful if it is used properly and the complications are managed carefully.

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APA: Copy

FERESHTEHKHOU, M.A., ZARGHAMI, N.A., & NOURINIA, R.. (2006). STUDY OF MITOMYCIN C APPLICATION IN TRABECULECTOMY OF HIGH RISK PATIENTS. PHARMACEUTICAL SCIENCES, -(1), 41-46. SID. https://sid.ir/paper/48501/en

Vancouver: Copy

FERESHTEHKHOU M.A., ZARGHAMI N.A., NOURINIA R.. STUDY OF MITOMYCIN C APPLICATION IN TRABECULECTOMY OF HIGH RISK PATIENTS. PHARMACEUTICAL SCIENCES[Internet]. 2006;-(1):41-46. Available from: https://sid.ir/paper/48501/en

IEEE: Copy

M.A. FERESHTEHKHOU, N.A. ZARGHAMI, and R. NOURINIA, “STUDY OF MITOMYCIN C APPLICATION IN TRABECULECTOMY OF HIGH RISK PATIENTS,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 41–46, 2006, [Online]. Available: https://sid.ir/paper/48501/en

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