IMPROVED TABLETTING PROPERTIES OF IBUPROFEN USING EVAPORATIVE PRECIPITATION WITH GELATIN

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MAGHSOODI M.; KIAFAR F.; DELF LOVEYMI B.

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Journal: PHARMACEUTICAL SCIENCES Year:2011 | Volume:17 | Issue:1 Page(s): 19-26

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Information Journal Paper

Title

IMPROVED TABLETTING PROPERTIES OF IBUPROFEN USING EVAPORATIVE PRECIPITATION WITH GELATIN

Author(s)

MAGHSOODI M. | KIAFAR F. | DELF LOVEYMI B. | Issue Writer Certificate

Keywords

IBUPROFENQ1

GELATINQ1

CO-PRECIPITATIONQ1

CRYSTALLIZATIONQ1

Abstract

Objectives: IBUPROFEN is a problematic drug in tableting due to its high cohaesivity and viscoelastic properties. In this study coprecipitation of IBUPROFEN with varying concentration of GELATIN to optimize properties of IBUPROFEN was carried out.Methods: Optical microscopy and differential scanning calorimetry (DSC) were used to investigate the physical characteristics of the co-precipitates. The dissolution behavior, flowability and compaction properties of various batches were also studied.Results: Co-presipitation of drug with GELATIN led to a change in habit from needle to plate shape crystals. The co-presipitates showed improved flow properties, while no change in dissolution rate of them was observed compared with IBUPROFEN alone. All of the obtained co-presipitates exhibited significantly improved tableting behavior compared with drug crystals alone. Due to the fact that the polymer covering the drug particles increases and changes the nature of the surface area available for interparticulate bonds between particles. DSC experiment showed that drug particles, in co-presipitates samples, did not undergo structural modifications.Conclusion: The study highlights the influence of polymeric additives on CRYSTALLIZATION process leading to modified performance.

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APA: Copy

MAGHSOODI, M., KIAFAR, F., & DELF LOVEYMI, B.. (2011). IMPROVED TABLETTING PROPERTIES OF IBUPROFEN USING EVAPORATIVE PRECIPITATION WITH GELATIN. PHARMACEUTICAL SCIENCES, 17(1), 19-26. SID. https://sid.ir/paper/48568/en

Vancouver: Copy

MAGHSOODI M., KIAFAR F., DELF LOVEYMI B.. IMPROVED TABLETTING PROPERTIES OF IBUPROFEN USING EVAPORATIVE PRECIPITATION WITH GELATIN. PHARMACEUTICAL SCIENCES[Internet]. 2011;17(1):19-26. Available from: https://sid.ir/paper/48568/en

IEEE: Copy

M. MAGHSOODI, F. KIAFAR, and B. DELF LOVEYMI, “IMPROVED TABLETTING PROPERTIES OF IBUPROFEN USING EVAPORATIVE PRECIPITATION WITH GELATIN,” PHARMACEUTICAL SCIENCES, vol. 17, no. 1, pp. 19–26, 2011, [Online]. Available: https://sid.ir/paper/48568/en

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