THE EFFECTS OF VARIOUS POLYETHYLENE GLYCOLS (PEGS) AND DIFFERENT SOLID DISPERSION ROCESSES ON COMPRESSIBILITY CHARACTERISTICS OF ACETAMINOPHENE POWDER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHOKRI J.; NOKHOUDCHI A.; LOTFI B.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PHARMACEUTICAL SCIENCES Year:2004 | Volume:- | Issue:1 Page(s): 117-128

Download Full-Text

Persian Verion

View:

1,435

Download:

Cites:

Information Journal Paper

Title

THE EFFECTS OF VARIOUS POLYETHYLENE GLYCOLS (PEGS) AND DIFFERENT SOLID DISPERSION ROCESSES ON COMPRESSIBILITY CHARACTERISTICS OF ACETAMINOPHENE POWDER

Author(s)

SHOKRI J. | NOKHOUDCHI A. | LOTFI B. | Issue Writer Certificate

Keywords

ACETAMINOPHENQ2

COMPRESSIBILITYQ2

PEGSQ3

SOLID DISPERSIONSQ3

Abstract

The COMPRESSIBILITY of drug powders is one of the most important factors for tablet preparing by direct compression method so, different studies have been done for COMPRESSIBILITY improvement of poorly compressible drug powders. ACETAMINOPHEN is one of the most currently used drugs with poor COMPRESSIBILITY features which different methods have been established for improving COMPRESSIBILITY of that. Solid dispersion methods are effective techniques for this purpose. In this study, we tried to improve COMPRESSIBILITY characteristics of ACETAMINOPHEN by using these techniques and PEGS as drug carriers. Various PEGS (2000, 6000 and 20000) with different carrier-drug ratios (1:5, 1:10, 1:15, 1:20 and 1:30) were used for the preparationof SOLID DISPERSIONS by using co-grinding and co-evaporation techniques. The samples compressed to tablets under different compression forces (50, 100, 150, 200 and 250 Kg/cm2).Hardness of prepared tablets were measured and compared with the tablets prepared from pure drug (PD), treated drugs (TDs) and physical mixtures (PMs) with the same polymer- drug ratios. XRD spectra were taken from samples for determining any crystalline changes during solid dispersion processes. The results showed further COMPRESSIBILITY in SOLID DISPERSIONS compared to PD, PTs and PMs with the same polymer-drug ratios. In the case of PMs, there was a direct proportionality between COMPRESSIBILITY characteristics and polymer ratios. TDs prepared by both co-grinding and co-evaporation methods also showed greater COMPRESSIBILITY than tablets made of PD. The COMPRESSIBILITY improvement in the solid dispersion prepared with co evaporation method was more predictable and re producible than those made with co-grinding method. This study demonstrated that co-evaporation technique and PEG carriers are. very useful in COMPRESSIBILITY improvement of ACETAMINOPHEN powder.

Cites

No record.

References

No record.

Cite

APA: Copy

SHOKRI, J., NOKHOUDCHI, A., & LOTFI, B.. (2004). THE EFFECTS OF VARIOUS POLYETHYLENE GLYCOLS (PEGS) AND DIFFERENT SOLID DISPERSION ROCESSES ON COMPRESSIBILITY CHARACTERISTICS OF ACETAMINOPHENE POWDER. PHARMACEUTICAL SCIENCES, -(1), 117-128. SID. https://sid.ir/paper/48572/en

Vancouver: Copy

SHOKRI J., NOKHOUDCHI A., LOTFI B.. THE EFFECTS OF VARIOUS POLYETHYLENE GLYCOLS (PEGS) AND DIFFERENT SOLID DISPERSION ROCESSES ON COMPRESSIBILITY CHARACTERISTICS OF ACETAMINOPHENE POWDER. PHARMACEUTICAL SCIENCES[Internet]. 2004;-(1):117-128. Available from: https://sid.ir/paper/48572/en

IEEE: Copy

J. SHOKRI, A. NOKHOUDCHI, and B. LOTFI, “THE EFFECTS OF VARIOUS POLYETHYLENE GLYCOLS (PEGS) AND DIFFERENT SOLID DISPERSION ROCESSES ON COMPRESSIBILITY CHARACTERISTICS OF ACETAMINOPHENE POWDER,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 117–128, 2004, [Online]. Available: https://sid.ir/paper/48572/en

Related Journal Papers