STUDY ON THE RELEASE OF ACETAZOLAMIDE FROM MATRICES CONTAINING TRAGACANTH AND ACACIA GUMS

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BARZEGAR JALALI M.; SIAHI SHADBAD M.R.; AZARMI SH.; BARZEGAR JALALI A.; MOHAMMADI GHOBAD; ADIBKIA KH.

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Journal: PHARMACEUTICAL SCIENCES Year:2007 | Volume:- | Issue:4 Page(s): 21-28

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Title

STUDY ON THE RELEASE OF ACETAZOLAMIDE FROM MATRICES CONTAINING TRAGACANTH AND ACACIA GUMS

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Keywords

ACETAZOLAMIDEQ2

MATRIXQ2

SUSTAINED-RELEASEQ2

TRAGACANTH GUMQ2

ACACIA GUMQ2

Abstract

Objectives: ACETAZOLAMIDE, a carbonic anhydrase inhibitor, is most efficient and beneficial in the treatment of glaucoma when used as a sustained release form. In the present work some sustained release matrices of the drug were formulated.Methods: Tragacanth and ACACIA GUMs matrices containing 500 mg of ACETAZOLAMIDE with ratios of gum to drug (RG/D) between 0.1-1 were formulated and the release study was conducted in buffer solution (pH=7.4) using USP dissolution apparatus I for 480 min.Results: The drug release was affected by the kind of the gum as well as the RG/D values. In order to assess the efficiency of the gums, percent of drug dissolved up to any time was plotted against RG/D. The plot was named as gum efficiency curve which contained ascending and descending parts indicating two opposite effects of the gums on drug release i.e release increasing effect up to a certain RG/D and then at higher RG/Ds releases decreasing effect. The corresponding turning points from ascending to descending part were 0.45 for tragacanth and 0.55 for ACACIA GUM. Beyond these values both gums decreased the release with different efficiency. From release decreasing point of view tragacanth was much more efficient than ACACIA GUM as it was evident from steeper slopes of its descending efficiency curves. The most suitable kinetic model for tragacanth release was zero order one with rate constant of 0.0007 - 0.0011 fraction/min whereas Weibull and log probability models were applicable for acacia matrices.Conclusion: Because of zero order kinetic as well as stronger release retardation efficiency the tragacanth matrices were superior to acacia matrices.

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APA: Copy

BARZEGAR JALALI, M., SIAHI SHADBAD, M.R., AZARMI, SH., BARZEGAR JALALI, A., MOHAMMADI, GHOBAD, & ADIBKIA, KH.. (2007). STUDY ON THE RELEASE OF ACETAZOLAMIDE FROM MATRICES CONTAINING TRAGACANTH AND ACACIA GUMS. PHARMACEUTICAL SCIENCES, -(4), 21-28. SID. https://sid.ir/paper/48623/en

Vancouver: Copy

BARZEGAR JALALI M., SIAHI SHADBAD M.R., AZARMI SH., BARZEGAR JALALI A., MOHAMMADI GHOBAD, ADIBKIA KH.. STUDY ON THE RELEASE OF ACETAZOLAMIDE FROM MATRICES CONTAINING TRAGACANTH AND ACACIA GUMS. PHARMACEUTICAL SCIENCES[Internet]. 2007;-(4):21-28. Available from: https://sid.ir/paper/48623/en

IEEE: Copy

M. BARZEGAR JALALI, M.R. SIAHI SHADBAD, SH. AZARMI, A. BARZEGAR JALALI, GHOBAD MOHAMMADI, and KH. ADIBKIA, “STUDY ON THE RELEASE OF ACETAZOLAMIDE FROM MATRICES CONTAINING TRAGACANTH AND ACACIA GUMS,” PHARMACEUTICAL SCIENCES, vol. -, no. 4, pp. 21–28, 2007, [Online]. Available: https://sid.ir/paper/48623/en

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