ROLE OF FISH MEAT PREPARED AT HIGH TEMPERATURE IN MICE SKIN TUMORIGENESIS

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REZAZADEH HOSSEIN; BABAEI HOSSEIN; SIAHI M.R.; TAHERABADI M.A.

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Journal: PHARMACEUTICAL SCIENCES Year:2003 | Volume:- | Issue:2 Page(s): 39-48

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Title

ROLE OF FISH MEAT PREPARED AT HIGH TEMPERATURE IN MICE SKIN TUMORIGENESIS

Author(s)

REZAZADEH HOSSEIN | BABAEI HOSSEIN | SIAHI M.R. | TAHERABADI M.A. | Issue Writer Certificate

Keywords

FISHQ3

7Q3

12-DIMETHYLBENZ(A)ANTHRACENEQ3

LIPID PEROXIDATIONQ2

SKIN TUMORIGENESISQ3

Abstract

Marine product especially FISH prepared at high temperature used medicinally in treatment of various human diseases by old traditional system of medicine, but polycyclic aromatic hydrocarbons a group of chemicals formed during high temperature cooking of meat and FISH reported to be potent mutagens and carcinogens. However, the mechanism by which cooked meat enhanced chemically induced carcinogenesis is not known. In this study we show that fried FISH meat acts as strong turnor promoter in mouse skin. Female Albino Swiss mice were initiated by DMBA 7,12- Dimethylbenz (a) anthracene and promoted by Croton oil in addition a group of animals were also received seafood 200 mg/mouse/week for a period of 40 weeks. These animals showed a significant enhancement of tumors and carcinoma incidence. Biochemical estimation was the measurement of LIPID PEROXIDATION, the parameter is indicative of free radical injury and cancer induction. Also there were significant enhancement of LIPID PEROXIDATION in those animals receiving seafood. So an induction of LIPID PEROXIDATION in these group of animals suggests that oxidative stress may be responsible for such an observed augmentation of cutaneous carcinogenesis in mice. Our result also indicates that seafood prepared at high temperature probably through the generation of free radical plays an important role in skin tumor genesis. The higher conversion of benign tumors in to malignant carcinoma strongly support our hypothesis.

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APA: Copy

REZAZADEH, HOSSEIN, BABAEI, HOSSEIN, SIAHI, M.R., & TAHERABADI, M.A.. (2003). ROLE OF FISH MEAT PREPARED AT HIGH TEMPERATURE IN MICE SKIN TUMORIGENESIS. PHARMACEUTICAL SCIENCES, -(2), 39-48. SID. https://sid.ir/paper/48652/en

Vancouver: Copy

REZAZADEH HOSSEIN, BABAEI HOSSEIN, SIAHI M.R., TAHERABADI M.A.. ROLE OF FISH MEAT PREPARED AT HIGH TEMPERATURE IN MICE SKIN TUMORIGENESIS. PHARMACEUTICAL SCIENCES[Internet]. 2003;-(2):39-48. Available from: https://sid.ir/paper/48652/en

IEEE: Copy

HOSSEIN REZAZADEH, HOSSEIN BABAEI, M.R. SIAHI, and M.A. TAHERABADI, “ROLE OF FISH MEAT PREPARED AT HIGH TEMPERATURE IN MICE SKIN TUMORIGENESIS,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 39–48, 2003, [Online]. Available: https://sid.ir/paper/48652/en

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