TOPICAL ANTI- INFLAMMATORY ACTIVITY OF EXTRACT OF STACHYS INFLATA ON CARRAGEEN AN AND UV INDUCED INFLAMMATION ON RAT PAW

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GARJANI A.; MALEK N.; ETERAF OSKOUEI T.; NAZEMIEH H.; SOLEIMANI POYA M.

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Journal: PHARMACEUTICAL SCIENCES Year:2003 | Volume:- | Issue:1 Page(s): 57-64

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Title

TOPICAL ANTI- INFLAMMATORY ACTIVITY OF EXTRACT OF STACHYS INFLATA ON CARRAGEEN AN AND UV INDUCED INFLAMMATION ON RAT PAW

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Keywords

INFLAMMATIONQ3

STACHYS INFLATAQ3

ERYTHEMAQ3

TOPICALQ3

Abstract

Exracts obtained from aerial parts of starchy inflate have been used in Iranian folk medicine in infective, rhumatic and other inflammatory disorders. We previously showed that the systemic administration of the hydroalcoholic extract of the plant have a marked anti-inflammatory effect on carrageenan induced INFLAMMATION. In the present study, TOPICAL anti- inflammatory activity of total hydroalcoholic exract isolated from aerial parts of STACHYS INFLATA was investigated in two inflammatory models in rats, carrageenan induced paw oedema and UV-induced ERYTHEMA. Administration of gel formulation of Stachys inflate containing 1and 5 percent of the hydro-alcoholic extracts on rat paw following carrageenan injection in hourly interval from 1-4 hours afterwards did not affect the inflammatory responses but the gel formulation and the ethanolic solution of the extract reduced the ERYTHEMA 4 and 24 hours following UV-exposure. The extract gels (1% and 5%) reduced the ERYTHEMA from scale 3 in control to 2±0 (p<0.01) and 2.25±0.25 (p<0.05) 4 and 24 hours following 90 seconds UV exposure, respectively. The ethanolic solution of the extract 15 and 30 mg/ml also reduced the ERYTHEMA to 2.25±0.25 (p<0.01) and 1.8±0.2 (p<0.001) 4hours following UV exposure; respectively. Similary 24 hours after UV exposure the score of ERYTHEMA was reduced significantly (p<0.001) to 2 and 1.1±0.1 respectively. Additionally non of formulations showed effect on scabiation after 24 hours.

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APA: Copy

GARJANI, A., MALEK, N., ETERAF OSKOUEI, T., NAZEMIEH, H., & SOLEIMANI POYA, M.. (2003). TOPICAL ANTI- INFLAMMATORY ACTIVITY OF EXTRACT OF STACHYS INFLATA ON CARRAGEEN AN AND UV INDUCED INFLAMMATION ON RAT PAW . PHARMACEUTICAL SCIENCES, -(1), 57-64. SID. https://sid.ir/paper/48700/en

Vancouver: Copy

GARJANI A., MALEK N., ETERAF OSKOUEI T., NAZEMIEH H., SOLEIMANI POYA M.. TOPICAL ANTI- INFLAMMATORY ACTIVITY OF EXTRACT OF STACHYS INFLATA ON CARRAGEEN AN AND UV INDUCED INFLAMMATION ON RAT PAW . PHARMACEUTICAL SCIENCES[Internet]. 2003;-(1):57-64. Available from: https://sid.ir/paper/48700/en

IEEE: Copy

A. GARJANI, N. MALEK, T. ETERAF OSKOUEI, H. NAZEMIEH, and M. SOLEIMANI POYA, “TOPICAL ANTI- INFLAMMATORY ACTIVITY OF EXTRACT OF STACHYS INFLATA ON CARRAGEEN AN AND UV INDUCED INFLAMMATION ON RAT PAW ,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 57–64, 2003, [Online]. Available: https://sid.ir/paper/48700/en

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