COMPARISON OF EFFICACY OF TWO METHODS FOR POST OPRATING SHIVERING (PETHIDIN & DOXAPRAM) IN INCREASING THE ARTERIAL OXYGEN SATURATION (SAO2)

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HOSSEINZADEH H.; AIDI M.; KOLAHDOUZAN KH.

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Journal: PHARMACEUTICAL SCIENCES Year:2003 | Volume:- | Issue:1 Page(s): 29-36

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Title

COMPARISON OF EFFICACY OF TWO METHODS FOR POST OPRATING SHIVERING (PETHIDIN & DOXAPRAM) IN INCREASING THE ARTERIAL OXYGEN SATURATION (SAO2)

Author(s)

HOSSEINZADEH H. | AIDI M. | KOLAHDOUZAN KH. | Issue Writer Certificate

Keywords

SHIVERINGQ3

PETHIDINQ3

DOXAPRAMQ3

SAO2Q3

Abstract

SHIVERING occurs for heat production to maintain body temperature within its normal values and causes unexpected effects snch as: dyscom fort because of patients hypotermic, pain, increased oxygen demand, increased CO2 production, increased tidal volume, cardiac output, heart rate, blood pressure and decrease in mixed Venus blood O2 saturation, acidosis, hypoxia and increase in intra occular and intra cranial pressure, wound stretching and dehiscence. since SHIVERING has been reported in %40 of post operative patients and because of above mentioned side effects, two methods for treatment of SHIVERING (pethidin & DOXAPRAM) have been studied and compared. In this prospective study, the efficacy of two therapeutic methods for SHIVERING in arterial oxygen saturation has been studied. Patients in anesthetic classes: ASA I & II who had ENT, abdominal surgery, brain and urologic operations and had SHIVERING in post operation period have been treated randomly with 0.33 mg/kg PETHIDINe or 1mg/kg DOXAPRAM. Vital signs and SAO2 during SHIVERING and after treatment have been compared with each other and analyzed. Mean SAO2 during SHIVERING was %93.76 and increased to %97.92 with treatment and it was significant (p<0.0001). This increase in PETHIDINe group in comparison with DOXAPRAM was greater and significant (p<0.03). Systolic blood pressure has been decreased from 130/41 mmHg (before treatment) to 120/22 mmHg (after treatment) and was significant (p<0.0004) wherese diastolic blood pressure has been decreased from 82/62 mmHg to 79/46 mmHg in which the difference was significant (p<0.0002). These changes were greater in PETHIDINe group than DOXAPRAM group. Because of the efficacy of PETHIDINe therapy in increasing SAO2 and decreasing the unexpected cardiovascular response to SHIVERING in comparison with DOXAPRAM, we recommend PETHIDINe therapy for SHIVERING in all patients especially with ischemic heart disease and high risk patients.

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APA: Copy

HOSSEINZADEH, H., AIDI, M., & KOLAHDOUZAN, KH.. (2003). COMPARISON OF EFFICACY OF TWO METHODS FOR POST OPRATING SHIVERING (PETHIDIN & DOXAPRAM) IN INCREASING THE ARTERIAL OXYGEN SATURATION (SAO2). PHARMACEUTICAL SCIENCES, -(1), 29-36. SID. https://sid.ir/paper/48704/en

Vancouver: Copy

HOSSEINZADEH H., AIDI M., KOLAHDOUZAN KH.. COMPARISON OF EFFICACY OF TWO METHODS FOR POST OPRATING SHIVERING (PETHIDIN & DOXAPRAM) IN INCREASING THE ARTERIAL OXYGEN SATURATION (SAO2). PHARMACEUTICAL SCIENCES[Internet]. 2003;-(1):29-36. Available from: https://sid.ir/paper/48704/en

IEEE: Copy

H. HOSSEINZADEH, M. AIDI, and KH. KOLAHDOUZAN, “COMPARISON OF EFFICACY OF TWO METHODS FOR POST OPRATING SHIVERING (PETHIDIN & DOXAPRAM) IN INCREASING THE ARTERIAL OXYGEN SATURATION (SAO2),” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 29–36, 2003, [Online]. Available: https://sid.ir/paper/48704/en

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