STUDY OF THE HYPOGLYCEMIC ACTIVITY OF THE HYDROALCOHOLIC EXTRACT OF URTICA DIOICA IN NORMAL AND DIABETIC RATSS

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FATHI AZAD F.; GARJANI A.R.; MALEKI N.; RANJ DOUST S.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:2 Page(s): 65-69

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Title

STUDY OF THE HYPOGLYCEMIC ACTIVITY OF THE HYDROALCOHOLIC EXTRACT OF URTICA DIOICA IN NORMAL AND DIABETIC RATSS

Author(s)

FATHI AZAD F. | GARJANI A.R. | MALEKI N. | RANJ DOUST S. | Issue Writer Certificate

Keywords

URTICA DIOICA; HYPOGLYCEMIAQ2

DIABETESQ2

BLOOD GLUCOSEQ2

Abstract

OBJECTIVES: Uritca dioica (stinging nettle) has been used in Irarian traditional medicine in the treatment of DIABETES. In this study the BLOOD GLUCOSE lowering effect of uritca dioica leaves extract was investigated in wistar rats. METHODS: wistar rats were allocated in two groups of normal and diabetic (induced by streptozotocin; ip). Animals in each group were subdivided into two groups of 5 that received hydroalcoholic extract of Uritca dioica either interaperitoneally (ip) or orally. The BLOOD GLUCOSE was determined by using a Glucometer. RESULTS: Oral and ip administration of hydroalcoholic extract of the plant showed a strong glucose lowering effect only on streptozotocin (STZ) induced diabetic rats. In contrast, the extract did not show hypoglycemic effect in normal rats. Even the extract in high doses produced a mild but a significant hyperglycemia in early hours after ip injection. Orally administrated extract in doses of 500 and 1000 mg/kg produced 20.8 and 23.7 percent reduction, respectively, in the BLOOD GLUCOSE level 24 hours after DIABETES induction. The decrease of STZ-induced hyperglycemia has reached to 33 and 44% of the control value 24 hours after the induction of DIABETES with 25 and 50 mg/kg of ip injected extract. These effects were persistent during 48 hours. CONCLUSION: The results indicate that nettle has a significant hypoglycemic effect on STZ-induced diabetic rats a type II diabetic model.

Cites

EFFECT OF ALCOHOLIC EXTRACTS FENUGREEK SEEDS (TRIGONELLA FOENUM GRACEUM L.) IN THE ACTIVITY OF HEPATIC ENZYMES IN NORMAL AND DIABETIC RATS

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APA: Copy

FATHI AZAD, F., GARJANI, A.R., MALEKI, N., & RANJ DOUST, S.. (2005). STUDY OF THE HYPOGLYCEMIC ACTIVITY OF THE HYDROALCOHOLIC EXTRACT OF URTICA DIOICA IN NORMAL AND DIABETIC RATSS. PHARMACEUTICAL SCIENCES, -(2), 65-69. SID. https://sid.ir/paper/48715/en

Vancouver: Copy

FATHI AZAD F., GARJANI A.R., MALEKI N., RANJ DOUST S.. STUDY OF THE HYPOGLYCEMIC ACTIVITY OF THE HYDROALCOHOLIC EXTRACT OF URTICA DIOICA IN NORMAL AND DIABETIC RATSS. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(2):65-69. Available from: https://sid.ir/paper/48715/en

IEEE: Copy

F. FATHI AZAD, A.R. GARJANI, N. MALEKI, and S. RANJ DOUST, “STUDY OF THE HYPOGLYCEMIC ACTIVITY OF THE HYDROALCOHOLIC EXTRACT OF URTICA DIOICA IN NORMAL AND DIABETIC RATSS,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 65–69, 2005, [Online]. Available: https://sid.ir/paper/48715/en

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