PROTECTIVE EFFECT OF THE HYDROALCHOLIC EXTRACT OF URTICA DIOICA LEAVES ON BLOOD GLUCOSE CONCENTRATION AND β-CELLS IN HYPERGLYCEMIC RATS

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GOL ALIPOUR M.J.; KHOURI V.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2007 | Volume:9 | Issue:1 (36) Page(s): 7-13

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Title

PROTECTIVE EFFECT OF THE HYDROALCHOLIC EXTRACT OF URTICA DIOICA LEAVES ON BLOOD GLUCOSE CONCENTRATION AND β-CELLS IN HYPERGLYCEMIC RATS

Author(s)

GOL ALIPOUR M.J. | KHOURI V. | Issue Writer Certificate

Keywords

URTICA DIOICAQ3

HYPERGLYCEMIAQ3

DIABETESQ2

β-CELLSQ2

STREPTOZOTOCINQ3

HYDROALCOHOL EXTRACTQ2

Abstract

Background and objective: URTICA DIOICA has been introduced with hypoglycemic activity in iranian traditional medicine. There are some reports with different results about the hypoglycemic activity of URTICA DIOICA. This study was done to determine the protective effect of the hydroalcholic extract of URTICA DIOICA leaves on HYPERGLYCEMIA and regeneration of b-cells in hyperglycemic rats.Methods: In this experimental study, 30 wistar rats were allocated in groups of normal, diabetic and treatment. In treatment group, animals received hydroalcholic extract of URTICA DIOICA 100 mg/kg/day intraperitoneally for five days and then HYPERGLYCEMIA in rats induced by 80 mg/kg STREPTOZOTOCIN. The blood glucose concentration was measured by using a glucometer in 1st, 3rd and 5th weeks. In the end of 5th weeks the animals in each group were sacrificed by ether anesthesia and whole pancreas in three groups extracted and beta cells were counted in three groups by olympus microscope.Findings: Mean±SE of blood glucose concentrations in end of fifth weeks were 99.4±5.0, 454.7±34.5 and 303.6±50.56 in control, diabetic and treatment groups, respectively (p<0.05). The percentage of b-cells in control, diabetic and treatment groups were 73.6%, 1.9% and 22.9%, respectively. The percentage of b-cells in treatment group comparing with diabetic group was significant (p<0.05).Conclusion: This study showed that the protective administration of hydroalcholic extract of URTICA DIOICA has hypoglycemic effect and regeneration of b-cells of langerhans in hyperglycemic rats.

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References

EFFECT OF ALCOHOLIC EXTRACTS FENUGREEK SEEDS (TRIGONELLA FOENUM GRACEUM L.) IN THE ACTIVITY OF HEPATIC ENZYMES IN NORMAL AND DIABETIC RATS

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APA: Copy

GOL ALIPOUR, M.J., & KHOURI, V.. (2007). PROTECTIVE EFFECT OF THE HYDROALCHOLIC EXTRACT OF URTICA DIOICA LEAVES ON BLOOD GLUCOSE CONCENTRATION AND β-CELLS IN HYPERGLYCEMIC RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 9(1 (36)), 7-13. SID. https://sid.ir/paper/73194/en

Vancouver: Copy

GOL ALIPOUR M.J., KHOURI V.. PROTECTIVE EFFECT OF THE HYDROALCHOLIC EXTRACT OF URTICA DIOICA LEAVES ON BLOOD GLUCOSE CONCENTRATION AND β-CELLS IN HYPERGLYCEMIC RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2007;9(1 (36)):7-13. Available from: https://sid.ir/paper/73194/en

IEEE: Copy

M.J. GOL ALIPOUR, and V. KHOURI, “PROTECTIVE EFFECT OF THE HYDROALCHOLIC EXTRACT OF URTICA DIOICA LEAVES ON BLOOD GLUCOSE CONCENTRATION AND β-CELLS IN HYPERGLYCEMIC RATS,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 9, no. 1 (36), pp. 7–13, 2007, [Online]. Available: https://sid.ir/paper/73194/en

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