FORMULATION, ASSESSMENT AND COMPARISON OF THREE ANTIACNE PREPARATIONS

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GARAVI S.M.; FATHEHI A.; SHAMSIAN E.

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Journal: PHARMACEUTICAL SCIENCES Year:2002 | Volume:- | Issue:2 Page(s): 37-44

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Title

FORMULATION, ASSESSMENT AND COMPARISON OF THREE ANTIACNE PREPARATIONS

Author(s)

GARAVI S.M. | FATHEHI A. | SHAMSIAN E. | Issue Writer Certificate

Keywords

ACNEQ2

AZELAIC ACIDQ3

ERYTHROMYCINQ2

SULPHURQ3

RESORCINOLQ3

Abstract

ACNE vulgaris is a multifactorial disease, affecting the pilocebaceous folliculs and characterized by comedones, papules, pustuls, nodules and scars. In order to treat ACNE, different drugs including: keralolytics, antibiotics, sebum reducing agents and hormone therapy are used, or the other topical drugs as AZELAIC ACID (AZA) with herbal origin. In this study effectiveness of 15% AZA gel was compared with 4% ERYTHROMYCIN +1.2% zinc acetate lotion and 8% SULPHUR+2% RESORCINOL cream in treatment of mild-modrate (comedonal or populopustular) ACNE. After prepartion of these drugs, amount of their active ingredients on each formulation was determined titrimetrically and spectrophotometrically. Clinical tests were carried out on 100 volunteers under supervision of a dermatologist using samples. Results of assay indicated that lotion contained 3.6±0.1 gr/100gr ERYTHROMYCIN, 0.845±0.06 gr zinc acetate /100gr, the gel contained 12.3±2.9gr AZELAIC ACID/ 100gr and emulsion base 6.7±2.4 SULPHUR/ 100gr. Clinical results indicated that the average inflammatory and non inflammatory lesion count in each group had reduced after three months, but the percentage of reduction of comodones with AZA formulation was much greater than others (78.3% of volunteers showed good-excellent clinical response). Furthermore side effects of AZA were well toterated. Thus AZA formulation is capable to replace the older formulations.

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APA: Copy

GARAVI, S.M., FATHEHI, A., & SHAMSIAN, E.. (2002). FORMULATION, ASSESSMENT AND COMPARISON OF THREE ANTIACNE PREPARATIONS. PHARMACEUTICAL SCIENCES, -(2), 37-44. SID. https://sid.ir/paper/48723/en

Vancouver: Copy

GARAVI S.M., FATHEHI A., SHAMSIAN E.. FORMULATION, ASSESSMENT AND COMPARISON OF THREE ANTIACNE PREPARATIONS. PHARMACEUTICAL SCIENCES[Internet]. 2002;-(2):37-44. Available from: https://sid.ir/paper/48723/en

IEEE: Copy

S.M. GARAVI, A. FATHEHI, and E. SHAMSIAN, “FORMULATION, ASSESSMENT AND COMPARISON OF THREE ANTIACNE PREPARATIONS,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 37–44, 2002, [Online]. Available: https://sid.ir/paper/48723/en

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