PREPARATION OF AGGLOMERATED CRYSTALS OF LACTOSE FOR DIRECT TABLETTING BY THE SPHERICAL CRYSTALLIZATION TECHNIQUE

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MAGHSOUDI M.; NOKHOUDCHI A.; BARZEGAR JALALI M.; PORAMJAD B.

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Journal: PHARMACEUTICAL SCIENCES Year:2006 | Volume:- | Issue:4 Page(s): 1-8

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Title

PREPARATION OF AGGLOMERATED CRYSTALS OF LACTOSE FOR DIRECT TABLETTING BY THE SPHERICAL CRYSTALLIZATION TECHNIQUE

Author(s)

MAGHSOUDI M. | NOKHOUDCHI A. | BARZEGAR JALALI M. | PORAMJAD B. | Issue Writer Certificate

Keywords

LACTOSEQ2

SPHERICAL CRYSTALLIZATIONQ2

DIRECT TABLETINGQ2

Abstract

Objectives: LACTOSE is widely used as a filler or diluent in tablets and capsules and direct compresion grade of LACTOSE can be used to carry small quantities of drug and this permits tablet to be made without granulation. The aim of the present study was to produce LACTOSE agglomerates with high flow ability and compatibility using crystallization technique. Methods: The spherical crystal agglomeration of LACTOSE was carried out by non-solvent method, the solvent was water and nonsolvent was ethanol. The operation parameters of the experiment were the flow rate of ethanol, the temperatures difference between solvent and nonsolvent and solvent/nonsolvent ratio. Results: The flowability as represented by the angle of repose (from 42°to 26°) and Carr index of the agglomerates (from 33 to 15), was much improved compared to original powder. The agglomerates were easily packed by tapping and the packability was described by Kawakita and Kuno's equations. Thus, the excellent flowability and packability of the agglomerates were attributed to the increase in particle size and spherical shape. Agglomerates were compressed to compacts which had considerable hardness without capping. Conclusion: In conclusion, the rnicromeritic properties of agglomerated crystals, such as flowability, pakability and compactibility were improved profoundly resulting in successful DIRECT TABLETING without capping. The results from this study have identified many of the factors affecting the morphology of a-LACTOSE monohydrate during the SPHERICAL CRYSTALLIZATION process. Different a-LACTOSE monohydrate crystals with precisely defined morphologies can be produced by careful control of the crystallization conditions.

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APA: Copy

MAGHSOUDI, M., NOKHOUDCHI, A., BARZEGAR JALALI, M., & PORAMJAD, B.. (2006). PREPARATION OF AGGLOMERATED CRYSTALS OF LACTOSE FOR DIRECT TABLETTING BY THE SPHERICAL CRYSTALLIZATION TECHNIQUE. PHARMACEUTICAL SCIENCES, -(4), 1-8. SID. https://sid.ir/paper/48741/en

Vancouver: Copy

MAGHSOUDI M., NOKHOUDCHI A., BARZEGAR JALALI M., PORAMJAD B.. PREPARATION OF AGGLOMERATED CRYSTALS OF LACTOSE FOR DIRECT TABLETTING BY THE SPHERICAL CRYSTALLIZATION TECHNIQUE. PHARMACEUTICAL SCIENCES[Internet]. 2006;-(4):1-8. Available from: https://sid.ir/paper/48741/en

IEEE: Copy

M. MAGHSOUDI, A. NOKHOUDCHI, M. BARZEGAR JALALI, and B. PORAMJAD, “PREPARATION OF AGGLOMERATED CRYSTALS OF LACTOSE FOR DIRECT TABLETTING BY THE SPHERICAL CRYSTALLIZATION TECHNIQUE,” PHARMACEUTICAL SCIENCES, vol. -, no. 4, pp. 1–8, 2006, [Online]. Available: https://sid.ir/paper/48741/en

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