مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

12,407
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

THE EFFECTS OF EXOGENOUS LACTASE ON IMPROVING GASTROINTESTINAL SYMPTOMS IN PATIENTS WITH LACTOSE INTOLERANCE

Pages

  893-900

Abstract

 Background: LACTOSE intolerance is common in Asian population. Enzyme replacement therapy facilitates consumption of milk and dairy products for patients with LACTOSE intolerance. Clinical evidence in our clinics indicates a nonhomogeneity in improvement of symptoms after ingestion of solid form of exogenous LACTASE enzyme in patients. Therefore, we designed this study to evaluate the effectiveness of oral solid LACTASE enzyme in the clinical symptoms of patients with LACTOSE intolerance in Arak city.Methods: This randomized double blind placebo controlled trial was performed on 50 adult symptomatic patients with LACTOSE intolerance. Average age of the patients was 37.4 years and 44% were men. Every patient took LACTASE and placebo for one week respectively. Effects of these treatments on gastrointestinal symptom of patients were gathered by symptom evaluation questionnaire. Results were analyzed by SPSS software.Finding: The mean improvement of abdominal pain score after LACTASE was 1.56 ± 2.51 (P<0.001) and after placebo was 0.54 ± 0 (P<0.001). The mean improvement of flatulence score after LACTASE was 1.6 ± 1.91 (P<0.001) and after placebo was 0.42 ± 0.94 (P=0.03). The mean improvement of bloating score after LACTASE was 1.62 ± 1.79 (P<0.001) and after placebo was 0.56 (P<0.001) ± 0.88. The mean improvement of diarrhea score after LACTASE was 2.70 ± 3.06 (P<0.001) and after placebo was 0.54 ± 0.99 (P<0.001). The mean improvement of nausea and vomiting score after LACTASE was 0.24 ± 0.89 (P=0.63) and after placebo was 0.04 ± 0.19 (P=0.15). After ingestion of LACTASE, 19 patients had no improvement in abdominal pain score, 12 patients in flatulence score, 3 patients in nausea and vomiting score, 17 patients in bloating score, and 7 patients had no improvement in diarrhea score.Conclusion: LACTASE tablets significantly reduced clinical symptoms associated with LACTOSE intolerance compared with placebo; but improvement of symptoms were variable between patients.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    GHAHREMANI, RAMIN, & ASANJARANI, BEHZAD. (2011). THE EFFECTS OF EXOGENOUS LACTASE ON IMPROVING GASTROINTESTINAL SYMPTOMS IN PATIENTS WITH LACTOSE INTOLERANCE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 28(115), 893-900. SID. https://sid.ir/paper/50417/en

    Vancouver: Copy

    GHAHREMANI RAMIN, ASANJARANI BEHZAD. THE EFFECTS OF EXOGENOUS LACTASE ON IMPROVING GASTROINTESTINAL SYMPTOMS IN PATIENTS WITH LACTOSE INTOLERANCE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2011;28(115):893-900. Available from: https://sid.ir/paper/50417/en

    IEEE: Copy

    RAMIN GHAHREMANI, and BEHZAD ASANJARANI, “THE EFFECTS OF EXOGENOUS LACTASE ON IMPROVING GASTROINTESTINAL SYMPTOMS IN PATIENTS WITH LACTOSE INTOLERANCE,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 28, no. 115, pp. 893–900, 2011, [Online]. Available: https://sid.ir/paper/50417/en

    Related Journal Papers

    Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top