ENHANCEMENT OF OXAZEPAM DISSOLUTION RATE USING OXAZEPAM- SURFACTANT SOLID DISPERSIONS

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SHOKRI J.; AZARMI SH.; SABOURI A.; SHOKRI M.H.

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Journal: PHARMACEUTICAL SCIENCES Year:2006 | Volume:- | Issue:4 Page(s): 35-45

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Title

ENHANCEMENT OF OXAZEPAM DISSOLUTION RATE USING OXAZEPAM- SURFACTANT SOLID DISPERSIONS

Author(s)

SHOKRI J. | AZARMI SH. | SABOURI A. | SHOKRI M.H. | Issue Writer Certificate

Keywords

OXAZEPAMQ2

SURFACTANTQ3

SOLID DISPERSIONQ2

DISSOLUTION RATEQ2

Abstract

Objectives: OXAZEPAM is a practically water-insoluble drug which its oral absorption is limited by DISSOLUTION RATE in gastrointestinal fluids therefore enhancement of DISSOLUTION RATE can increase the rate and extent of its oral absorption. In this study, the effect of anionic (SLS), cationic (CTAB) and nonionic (Myrj 52) SURFACTANTs as carriers with different drug-carrier ratios (1:0.25, 1:0.5, I: 1 and 1:2) on DISSOLUTION RATE of OXAZEPAM from SOLID DISPERSIONs was evaluated. Methods: SOLID DISPERSIONs were made by using co-evaporation method with 85% hydroalcoholic mixture as solvent. DISSOLUTION RATE of samples was measured by USP standard dissolution tester apparatus (USP No: II) and UV spectrophotometer. XRD and FT-IR spectroscopy were taken for the determination of probable crystalline changes in drug and drug-carrier interaction during process respectively. Results: The results showed significant higher DISSOLUTION RATEs for SOLID DISPERSIONs with all ratios compared with physical mixtures, treated physical mixtures, treated and intact drug powder. Physical mixtures also had a significant higher DISSOLUTION RATEs over intact drug and treated drug powders. 1:0.25 was selected as optimum ratio for OXAZEPAM-SLS and OXAZEPAM-CTAB SOLID DISPERSIONs. 1:0.5 OXAZEPAM-Myrj52 ratios were also selected as optimum drug-carrier ratio for these SOLID DISPERSIONs. Solubility test results showed solubility enhancement ability of all SURFACTANTs. XRD and FT-IR spectra rejected any polymorphic changes or drug-carrier interaction during co-evaporation process. Conclusion: SOLID DISPERSION is very effective technique for improving DISSOLUTION RATE of practically insoluble drugs such as benzodiuazepines. SURFACTANTs are suitable carriers for low-dose and very low water-soluble drugs.

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APA: Copy

SHOKRI, J., AZARMI, SH., SABOURI, A., & SHOKRI, M.H.. (2006). ENHANCEMENT OF OXAZEPAM DISSOLUTION RATE USING OXAZEPAM- SURFACTANT SOLID DISPERSIONS. PHARMACEUTICAL SCIENCES, -(4), 35-45. SID. https://sid.ir/paper/48742/en

Vancouver: Copy

SHOKRI J., AZARMI SH., SABOURI A., SHOKRI M.H.. ENHANCEMENT OF OXAZEPAM DISSOLUTION RATE USING OXAZEPAM- SURFACTANT SOLID DISPERSIONS. PHARMACEUTICAL SCIENCES[Internet]. 2006;-(4):35-45. Available from: https://sid.ir/paper/48742/en

IEEE: Copy

J. SHOKRI, SH. AZARMI, A. SABOURI, and M.H. SHOKRI, “ENHANCEMENT OF OXAZEPAM DISSOLUTION RATE USING OXAZEPAM- SURFACTANT SOLID DISPERSIONS,” PHARMACEUTICAL SCIENCES, vol. -, no. 4, pp. 35–45, 2006, [Online]. Available: https://sid.ir/paper/48742/en

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