CYTOTOXIC EFFECT OF PLURONIC F127-POLY (METHYL VINYL ETHER-ALT-MALEIC ACID) MICELLES LOADED WITH DOXORUBICIN ON MCF-7 CELLS

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VARSHOSAZ JALEH; HASSANZADEH FARSHID; SADEGHI ALIABADI HOJJAT; LARIAN ZAHRA

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2013 | Volume:31 | Issue:241 Page(s): 876-884

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Title

CYTOTOXIC EFFECT OF PLURONIC F127-POLY (METHYL VINYL ETHER-ALT-MALEIC ACID) MICELLES LOADED WITH DOXORUBICIN ON MCF-7 CELLS

Author(s)

VARSHOSAZ JALEH | HASSANZADEH FARSHID | SADEGHI ALIABADI HOJJAT | LARIAN ZAHRA | Issue Writer Certificate

Keywords

PLURONIC F127Q2

POLY (METHYL VINYL ETHER-ALT-MALEIC ACID)Q1

MICELLESQ2

DOXORUBICINQ2

MCF-7Q2

MTT ASSAYQ2

Abstract

Background: DOXORUBICIN is used for treatment of different types of cancer including breast cancer. However, there are various side effects such as cardiotoxicity. Using a suitable drug delivery system such as polymeric MICELLES containing DOXORUBICIN may reduce these effects.Methods: MICELLES were prepared by direct dissolution method. After optimization according to their particle size, zeta potential, polydispersity index, loading efficiency and release of DOXORUBICIN, MICELLES were used for further tests of cytotoxicity on MCF-7 cell line by 3- (4, 5-Dimethylthiazol-2-yl) -2, 5 diphenyltetrazolium bromide (MTT) assay.Findings: The optimum targeted MICELLES with particle size of 419±38 nm, zeta potential of -13.3±1.2 mv, polydispersity index of 0.45±0.019, loading efficiency of 93.5±2.7 percent and drug release efficiency of 29.03±3.7 percent in different concentrations of 0.21, 0.26, 0.34, 47.0 and 0.78 mM showed higher cytotoxicity than blank MICELLES and free drug.Conclusion: PLURONIC F127-poly (methyl vinyl ether-alt-maleic acid) MICELLES showed more cytotoxicity than free drug against MCF-7 cell line.

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APA: Copy

VARSHOSAZ, JALEH, HASSANZADEH, FARSHID, SADEGHI ALIABADI, HOJJAT, & LARIAN, ZAHRA. (2013). CYTOTOXIC EFFECT OF PLURONIC F127-POLY (METHYL VINYL ETHER-ALT-MALEIC ACID) MICELLES LOADED WITH DOXORUBICIN ON MCF-7 CELLS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(241), 876-884. SID. https://sid.ir/paper/49694/en

Vancouver: Copy

VARSHOSAZ JALEH, HASSANZADEH FARSHID, SADEGHI ALIABADI HOJJAT, LARIAN ZAHRA. CYTOTOXIC EFFECT OF PLURONIC F127-POLY (METHYL VINYL ETHER-ALT-MALEIC ACID) MICELLES LOADED WITH DOXORUBICIN ON MCF-7 CELLS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(241):876-884. Available from: https://sid.ir/paper/49694/en

IEEE: Copy

JALEH VARSHOSAZ, FARSHID HASSANZADEH, HOJJAT SADEGHI ALIABADI, and ZAHRA LARIAN, “CYTOTOXIC EFFECT OF PLURONIC F127-POLY (METHYL VINYL ETHER-ALT-MALEIC ACID) MICELLES LOADED WITH DOXORUBICIN ON MCF-7 CELLS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 241, pp. 876–884, 2013, [Online]. Available: https://sid.ir/paper/49694/en

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