The Role of Exercise in Adaptation and Body Response to DoxorubicinInduced Cellular Toxicity: A Narrative Review Study

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HASHEMI CHASHEMI S.Z.; Hojati S.S.; DABIDI ROSHAN V.; JALALI DEHKORDI KH.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2020 | Volume:19 | Issue:8 Page(s): 869-888

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Title

The Role of Exercise in Adaptation and Body Response to DoxorubicinInduced Cellular Toxicity: A Narrative Review Study

Author(s)

HASHEMI CHASHEMI S.Z. | Hojati S.S. | DABIDI ROSHAN V. | JALALI DEHKORDI KH. | Issue Writer Certificate

Keywords

CancerQ2

DoxorubicinQ1

CytotoxicityQ2

ExerciseQ2

Abstract

Doxorubicin is an anthracycline antibiotic used for the treatment of a wide range of Cancers. But unfortunately, due to its accumulation within healthy tissues, DOX treatment results in side effects of cellular toxicity. DOX-induced cellular toxicity occurs as a result of increasing oxidative damage, resulting in apoptosis and cell death. There is currently no standard of care practice to prevent DOX-induced toxicity to off-target organs. Therefore, scientists and researchers are seeking to further development and improvement of the treatment for this deadly disease. Meanwhile, the combination of Exercise and chemotherapy is a promising method for efficiency and tolerance and reduction of side effects and drug resistance. Physical activities stimulate numerous beneficial biochemical adaptations resulting in a healthy phenotype in vulnerable tissues, without affecting the antineoplastic properties of DOX. Therefore, determining the appropriate Exercise regimen is important to prescribe those Cancer patients receiving DOX therapy because the patient's physical and medical conditions must be considered. The present review study investigates the cytotoxic effects of DOX on the heart, liver, kidney and lungs, discussing the benefits of the role of regular physical activity and potential mechanisms dealing with the positive effects of Exercise on each system.

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APA: Copy

HASHEMI CHASHEMI, S.Z., Hojati, S.S., DABIDI ROSHAN, V., & JALALI DEHKORDI, KH.. (2020). The Role of Exercise in Adaptation and Body Response to DoxorubicinInduced Cellular Toxicity: A Narrative Review Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 19(8 ), 869-888. SID. https://sid.ir/paper/376519/en

Vancouver: Copy

HASHEMI CHASHEMI S.Z., Hojati S.S., DABIDI ROSHAN V., JALALI DEHKORDI KH.. The Role of Exercise in Adaptation and Body Response to DoxorubicinInduced Cellular Toxicity: A Narrative Review Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2020;19(8 ):869-888. Available from: https://sid.ir/paper/376519/en

IEEE: Copy

S.Z. HASHEMI CHASHEMI, S.S. Hojati, V. DABIDI ROSHAN, and KH. JALALI DEHKORDI, “The Role of Exercise in Adaptation and Body Response to DoxorubicinInduced Cellular Toxicity: A Narrative Review Study,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 19, no. 8 , pp. 869–888, 2020, [Online]. Available: https://sid.ir/paper/376519/en

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