COMPARATIVE INVESTIGATION OF TSLC1 TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL OVARIAN SPECIMENS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NIKBAKHT DASTJERDI MEHDI; SHAHID POORFALLAH SEDIGHEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2013 | Volume:31 | Issue:245 Page(s): 1086-1095

Download Full-Text

Persian Verion

View:

951

Download:

Cites:

Information Journal Paper

Title

COMPARATIVE INVESTIGATION OF TSLC1 TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL OVARIAN SPECIMENS

Author(s)

NIKBAKHT DASTJERDI MEHDI | SHAHID POORFALLAH SEDIGHEH | Issue Writer Certificate

Keywords

OVARIAN CANCERQ2

TSLC1Q2

TUMOR SUPPRESSOR GENEQ2

IMMUNO-HISTOCHEMISTRYQ2

Abstract

Background: TSLC1 is a tumor suppressor protein its inactivation destroy the intracellular adhesion and connection between the membrane and cytoskeleton tend to malignant phenotype and metastasis.In this study, the expression of TSLC1 was examined in normal and cancerous OVARIAN CANCER specimens.Methods: 60 samples of OVARIAN CANCER and 60 adjacent normal tissues from the same tumor samples were studied. TSLC1 protein expression was evaluated by immunohistochemistry method. Percentage of cells stained from each tissue sections was checked with light microscope and Motic Advanced plus 2 software.Findings: The presence of brown cytoplasmic membrane, with or without brown membrane, was considered positive for TSLC1 expression. Protein expression in tumor tissue was significantly reduced compared to adjacent normal tissues (P<0.001). The reduction of protein expression was associated with lymph node metastasis (P=0.028) and more advanced tumor stages (P=0.032).Conclusion: According to the reduced expression of TSLC1 protein in tumor compared to normal samples in this study, expression of TSLC1 protein may be related to OVARIAN CANCER pathogenesis. On the other hand, reduced expression of TSLC1 protein can cause ovarian carcinoma to become aggressive. So, this protein can be used as a diagnostic molecular marker for patients with ovarian carcinoma.

Cites

DECISION MODELING FOR DIAGNOSIS AND SCREENING OF OVARIAN EPITHELIAL CANCER

References

No record.

Cite

APA: Copy

NIKBAKHT DASTJERDI, MEHDI, & SHAHID POORFALLAH, SEDIGHEH. (2013). COMPARATIVE INVESTIGATION OF TSLC1 TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL OVARIAN SPECIMENS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(245), 1086-1095. SID. https://sid.ir/paper/49774/en

Vancouver: Copy

NIKBAKHT DASTJERDI MEHDI, SHAHID POORFALLAH SEDIGHEH. COMPARATIVE INVESTIGATION OF TSLC1 TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL OVARIAN SPECIMENS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(245):1086-1095. Available from: https://sid.ir/paper/49774/en

IEEE: Copy

MEHDI NIKBAKHT DASTJERDI, and SEDIGHEH SHAHID POORFALLAH, “COMPARATIVE INVESTIGATION OF TSLC1 TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL OVARIAN SPECIMENS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 245, pp. 1086–1095, 2013, [Online]. Available: https://sid.ir/paper/49774/en

Related Journal Papers