COMPARATIVE INVESTIGATION OF DAL-1 TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL OVARIAN SPECIMENS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NIKBAKHT DASTJERDI MEHDI; ABDOLALI ZAHRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Isfahan Medical School Year:2013 | Volume:31 | Issue:250 Page(s): 1339-1350

Download Full-Text

Persian Verion

View:

929

Download:

Cites:

Information Journal Paper

Title

COMPARATIVE INVESTIGATION OF DAL-1 TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL OVARIAN SPECIMENS

Author(s)

NIKBAKHT DASTJERDI MEHDI | ABDOLALI ZAHRA | Issue Writer Certificate

Keywords

OVARIAN CANCERQ2

DALQ2

1Q2

TUMOR SUPPRESSOR GENEQ2

IMMUNOHISTOCHEMISTRYQ2

Abstract

Background: DAL-1 (differentially expressed in adenocarcinoma of the lung-1), located on chromosome 18 (18p11.3), has been identified as a TUMOR SUPPRESSOR GENE. DAL-1 is one member of cell adhesion molecules, play role in cytoskeleton organization with intracellular tight junctions. Inactivation of this gene can destroy the intracellular and cell-cytoskeleton adhesion, which induces malignancy and metastasis. We aimed to compare the DAL-1 tumor suppressor protein expression in cancerous and normal ovarian specimens.Methods: 60 samples of OVARIAN CANCER and 60 adjacent normal tissues from the same tumor samples were used. IMMUNOHISTOCHEMISTRY method used to investigate the expression of DAL-1 protein. For scrutiny of percentage of cells in stained tissue sections, we took advantage of optical microscope and motic advanced plus 2 software. The presence of brown cytoplasm, with or without brown membrane, was considered positive for the expression of DAL-1.Findings: Significantly, expression of DAL-1 protein was reduced in tumoral tissues compared with adjacent normal tissues (P<0.001). Also, the decrease of protein expression was statistically related with lymph node metastasis (P=0.036).Conclusion: According to the low incidence of DAL-1 protein in tumor samples compared to normal samples in this study, DAL-1 protein expression can be related with the pathogenesis of OVARIAN CANCER. On the other hand, significantly relation of the absence or reduce expression of this protein in cancerous samples with lymph node metastasis reveals that DAL-1 can be used as a diagnostic marker for OVARIAN CANCER patients.

Cites

No record.

References

No record.

Cite

APA: Copy

NIKBAKHT DASTJERDI, MEHDI, & ABDOLALI, ZAHRA. (2013). COMPARATIVE INVESTIGATION OF DAL-1 TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL OVARIAN SPECIMENS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(250), 1339-1350. SID. https://sid.ir/paper/50647/en

Vancouver: Copy

NIKBAKHT DASTJERDI MEHDI, ABDOLALI ZAHRA. COMPARATIVE INVESTIGATION OF DAL-1 TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL OVARIAN SPECIMENS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(250):1339-1350. Available from: https://sid.ir/paper/50647/en

IEEE: Copy

MEHDI NIKBAKHT DASTJERDI, and ZAHRA ABDOLALI, “COMPARATIVE INVESTIGATION OF DAL-1 TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL OVARIAN SPECIMENS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 250, pp. 1339–1350, 2013, [Online]. Available: https://sid.ir/paper/50647/en

Related Journal Papers